Mediastinal IgG4-Related Disease Manifesting as Superior Vena Cava Syndrome

Matthew R. DeLuzio, Negar Rassaei, Matthew D. Taylor, Michael F. Reed

Research output: Contribution to journalArticlepeer-review


Immunoglobulin G4 (IgG4)–related disease was first identified as a systemic condition in 2003 when extrapancreatic manifestations were identified in patients with autoimmune pancreatitis. Its peak incidence occurs in the fifth or sixth decades of life. Isolated extraaortic mediastinal involvement is extremely rare. This report describes a case of isolated extraaortic mediastinal IgG4-related disease encasing the superior vena cava (SVC) and manifesting as SVC syndrome in a 25-year-old man with no personal or family history of autoimmune disease. Resection with SVC reconstruction was performed.

Original languageEnglish (US)
Pages (from-to)e49-e51
JournalAnnals of Thoracic Surgery
Issue number1
StatePublished - Jul 2021

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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