Mediastinal IgG4-Related Disease Manifesting as Superior Vena Cava Syndrome

Matthew R. DeLuzio; Negar Rassaei; Matthew D. Taylor; Michael F. Reed

doi:10.1016/j.athoracsur.2020.10.064

Mediastinal IgG4-Related Disease Manifesting as Superior Vena Cava Syndrome

Matthew R. DeLuzio, Negar Rassaei, Matthew D. Taylor, Michael F. Reed

Research output: Contribution to journal › Article › peer-review

Abstract

Immunoglobulin G4 (IgG4)–related disease was first identified as a systemic condition in 2003 when extrapancreatic manifestations were identified in patients with autoimmune pancreatitis. Its peak incidence occurs in the fifth or sixth decades of life. Isolated extraaortic mediastinal involvement is extremely rare. This report describes a case of isolated extraaortic mediastinal IgG4-related disease encasing the superior vena cava (SVC) and manifesting as SVC syndrome in a 25-year-old man with no personal or family history of autoimmune disease. Resection with SVC reconstruction was performed.

Original language	English (US)
Pages (from-to)	e49-e51
Journal	Annals of Thoracic Surgery
Volume	112
Issue number	1
DOIs	https://doi.org/10.1016/j.athoracsur.2020.10.064
State	Published - Jul 2021

All Science Journal Classification (ASJC) codes

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.athoracsur.2020.10.064

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title = "Mediastinal IgG4-Related Disease Manifesting as Superior Vena Cava Syndrome",

abstract = "Immunoglobulin G4 (IgG4)–related disease was first identified as a systemic condition in 2003 when extrapancreatic manifestations were identified in patients with autoimmune pancreatitis. Its peak incidence occurs in the fifth or sixth decades of life. Isolated extraaortic mediastinal involvement is extremely rare. This report describes a case of isolated extraaortic mediastinal IgG4-related disease encasing the superior vena cava (SVC) and manifesting as SVC syndrome in a 25-year-old man with no personal or family history of autoimmune disease. Resection with SVC reconstruction was performed.",

author = "DeLuzio, {Matthew R.} and Negar Rassaei and Taylor, {Matthew D.} and Reed, {Michael F.}",

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AU - Reed, Michael F.

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AB - Immunoglobulin G4 (IgG4)–related disease was first identified as a systemic condition in 2003 when extrapancreatic manifestations were identified in patients with autoimmune pancreatitis. Its peak incidence occurs in the fifth or sixth decades of life. Isolated extraaortic mediastinal involvement is extremely rare. This report describes a case of isolated extraaortic mediastinal IgG4-related disease encasing the superior vena cava (SVC) and manifesting as SVC syndrome in a 25-year-old man with no personal or family history of autoimmune disease. Resection with SVC reconstruction was performed.

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Mediastinal IgG4-Related Disease Manifesting as Superior Vena Cava Syndrome

Abstract

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