Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial

Peter G. McGovern; Sandra A. Carson; Huiman X. Barnhart; Evan R. Myers; Richard S. Legro; Michael P. Diamond; Bruce R. Carr; William D. Schlaff; Christos Coutifaris; Nicholas A. Cataldo; Michael P. Steinkampf; John E. Nestler; Gabey Gosman; Phyllis C. Leppert; Linda C. Giudice

doi:10.1016/j.fertnstert.2007.09.004

Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial

Peter G. McGovern
, Sandra A. Carson
, Huiman X. Barnhart
, Evan R. Myers
, Richard S. Legro
, Michael P. Diamond
, Bruce R. Carr
, William D. Schlaff
, Christos Coutifaris
, Nicholas A. Cataldo
, Michael P. Steinkampf
, John E. Nestler
, Gabey Gosman
, Phyllis C. Leppert
, Linda C. Giudice

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Median adherence for both metformin and clomiphene citrate tablets was within acceptable limits and unrelated to ovulation: thus, failure to comply with physician recommendations for metformin dosing was not the reason for low ovulation and pregnancy rates in the PPCOS Trial.

Original language	English (US)
Pages (from-to)	1283-1286
Number of pages	4
Journal	Fertility and sterility
Volume	90
Issue number	4
DOIs	https://doi.org/10.1016/j.fertnstert.2007.09.004
State	Published - Oct 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.fertnstert.2007.09.004

Cite this

McGovern, P. G., Carson, S. A., Barnhart, H. X., Myers, E. R., Legro, R. S., Diamond, M. P., Carr, B. R., Schlaff, W. D., Coutifaris, C., Cataldo, N. A., Steinkampf, M. P., Nestler, J. E., Gosman, G., Leppert, P. C., & Giudice, L. C. (2008). Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial. Fertility and sterility, 90(4), 1283-1286. https://doi.org/10.1016/j.fertnstert.2007.09.004

@article{44a132f26f2447ed911769a1ce250275,

title = "Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial",

abstract = "We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Median adherence for both metformin and clomiphene citrate tablets was within acceptable limits and unrelated to ovulation: thus, failure to comply with physician recommendations for metformin dosing was not the reason for low ovulation and pregnancy rates in the PPCOS Trial.",

author = "McGovern, \{Peter G.\} and Carson, \{Sandra A.\} and Barnhart, \{Huiman X.\} and Myers, \{Evan R.\} and Legro, \{Richard S.\} and Diamond, \{Michael P.\} and Carr, \{Bruce R.\} and Schlaff, \{William D.\} and Christos Coutifaris and Cataldo, \{Nicholas A.\} and Steinkampf, \{Michael P.\} and Nestler, \{John E.\} and Gabey Gosman and Leppert, \{Phyllis C.\} and Giudice, \{Linda C.\}",

note = "Funding Information: Supported by National Institutes of Health/National Institute of Child Health and Human Development grants U10 HD27049 (C.C.), U01 HD38997 (E.R.M.), U10 HD39005 (M.P.D.), U10 HD27011 (S.A.C.), U10 HD33172 (M.P.S.), U10 HD38988 (B.R.C.), U10 HD38992 (R.S.L.), U10 HD38998 (W.D.S.), U10 HD38999 (P.G.M.), U54-HD29834 University of Virginia Center for Research in Reproduction Ligand Assay and Analysis Core, General Clinical Research Center grant MO1RR00056 to the University of Pittsburgh, and a General Clinical Research Center grant MO1 RR 10732 and construction grant C06 RR016499 to Pennsylvania State University. P.G.M. received grant support from Ferring Pharmaceuticals, Suffern, N.Y. ",

year = "2008",

month = oct,

doi = "10.1016/j.fertnstert.2007.09.004",

language = "English (US)",

volume = "90",

pages = "1283--1286",

journal = "Fertility and sterility",

issn = "0015-0282",

publisher = "Elsevier Inc.",

number = "4",

}

McGovern, PG, Carson, SA, Barnhart, HX, Myers, ER, Legro, RS, Diamond, MP, Carr, BR, Schlaff, WD, Coutifaris, C, Cataldo, NA, Steinkampf, MP, Nestler, JE, Gosman, G, Leppert, PC & Giudice, LC 2008, 'Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial', Fertility and sterility, vol. 90, no. 4, pp. 1283-1286. https://doi.org/10.1016/j.fertnstert.2007.09.004

Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial. / McGovern, Peter G.; Carson, Sandra A.; Barnhart, Huiman X. et al.
In: Fertility and sterility, Vol. 90, No. 4, 10.2008, p. 1283-1286.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial

AU - McGovern, Peter G.

AU - Carson, Sandra A.

AU - Barnhart, Huiman X.

AU - Myers, Evan R.

AU - Legro, Richard S.

AU - Diamond, Michael P.

AU - Carr, Bruce R.

AU - Schlaff, William D.

AU - Coutifaris, Christos

AU - Cataldo, Nicholas A.

AU - Steinkampf, Michael P.

AU - Nestler, John E.

AU - Gosman, Gabey

AU - Leppert, Phyllis C.

AU - Giudice, Linda C.

N1 - Funding Information: Supported by National Institutes of Health/National Institute of Child Health and Human Development grants U10 HD27049 (C.C.), U01 HD38997 (E.R.M.), U10 HD39005 (M.P.D.), U10 HD27011 (S.A.C.), U10 HD33172 (M.P.S.), U10 HD38988 (B.R.C.), U10 HD38992 (R.S.L.), U10 HD38998 (W.D.S.), U10 HD38999 (P.G.M.), U54-HD29834 University of Virginia Center for Research in Reproduction Ligand Assay and Analysis Core, General Clinical Research Center grant MO1RR00056 to the University of Pittsburgh, and a General Clinical Research Center grant MO1 RR 10732 and construction grant C06 RR016499 to Pennsylvania State University. P.G.M. received grant support from Ferring Pharmaceuticals, Suffern, N.Y.

PY - 2008/10

Y1 - 2008/10

N2 - We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Median adherence for both metformin and clomiphene citrate tablets was within acceptable limits and unrelated to ovulation: thus, failure to comply with physician recommendations for metformin dosing was not the reason for low ovulation and pregnancy rates in the PPCOS Trial.

AB - We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Median adherence for both metformin and clomiphene citrate tablets was within acceptable limits and unrelated to ovulation: thus, failure to comply with physician recommendations for metformin dosing was not the reason for low ovulation and pregnancy rates in the PPCOS Trial.

UR - https://www.scopus.com/pages/publications/52949098798

UR - https://www.scopus.com/pages/publications/52949098798#tab=citedBy

U2 - 10.1016/j.fertnstert.2007.09.004

DO - 10.1016/j.fertnstert.2007.09.004

M3 - Article

C2 - 18082737

AN - SCOPUS:52949098798

SN - 0015-0282

VL - 90

SP - 1283

EP - 1286

JO - Fertility and sterility

JF - Fertility and sterility

IS - 4

ER -

Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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