TY - JOUR
T1 - Meeting report – Alpine desmosome disease meeting 2024
T2 - advances and emerging topics in desmosomes and related diseases
AU - Waschke, Jens
AU - Amagai, Masayuki
AU - Becker, Christoph
AU - Delmar, Mario
AU - Duru, Firat
AU - Garrod, David R.
AU - Gerull, Brenda
AU - Green, Kathleen J.
AU - Hertl, Michael
AU - Kowalczyk, Andrew P.
AU - Niessen, Carien M.
AU - Nusrat, Asma
AU - Schinner, Camilla
AU - Schlegel, Nicolas
AU - Sivasankar, Sanjeevi
AU - Vielmuth, Franziska
AU - Spindler, Volker
N1 - Publisher Copyright:
© 2025. Published by The Company of Biologists.
PY - 2025/1
Y1 - 2025/1
N2 - Desmosomes are adhesive cell contacts abundant in tissues exposed to mechanical strain, such as the stratified and simple epithelia of the epidermis and mucous membranes, as well as the myocardium. Besides their role in mechanical cell cohesion, desmosomes also modulate pathways important for tissue differentiation, wound healing and immune responses. Dysfunctional desmosomes, resulting from pathogenic variants in genes encoding desmosomal components, autoantibodies targeting desmosomal adhesion molecules or inflammation, cause the life-threatening diseases arrhythmogenic cardiomyopathy and pemphigus and contribute to the pathogenesis of inflammatory bowel diseases. The Alpine Desmosome Disease Meeting 2024 (ADDM 2024), held in Grainau, Germany in October 2024, connected international researchers from basic sciences with clinical experts from dermatology, cardiology, gastroenterology and surgery. The participants discussed recent advances, identified hot topics in desmosome biology and disease and provided new concepts for pathogenesis and treatment approaches.
AB - Desmosomes are adhesive cell contacts abundant in tissues exposed to mechanical strain, such as the stratified and simple epithelia of the epidermis and mucous membranes, as well as the myocardium. Besides their role in mechanical cell cohesion, desmosomes also modulate pathways important for tissue differentiation, wound healing and immune responses. Dysfunctional desmosomes, resulting from pathogenic variants in genes encoding desmosomal components, autoantibodies targeting desmosomal adhesion molecules or inflammation, cause the life-threatening diseases arrhythmogenic cardiomyopathy and pemphigus and contribute to the pathogenesis of inflammatory bowel diseases. The Alpine Desmosome Disease Meeting 2024 (ADDM 2024), held in Grainau, Germany in October 2024, connected international researchers from basic sciences with clinical experts from dermatology, cardiology, gastroenterology and surgery. The participants discussed recent advances, identified hot topics in desmosome biology and disease and provided new concepts for pathogenesis and treatment approaches.
UR - https://www.scopus.com/pages/publications/85216519711
UR - https://www.scopus.com/pages/publications/85216519711#tab=citedBy
U2 - 10.1242/jcs.263796
DO - 10.1242/jcs.263796
M3 - Article
C2 - 39838950
AN - SCOPUS:85216519711
SN - 0021-9533
VL - 138
JO - Journal of Cell Science
JF - Journal of Cell Science
IS - 2
M1 - jcs263796
ER -