TY - JOUR
T1 - MEF-2 isoforms' (A-D) roles in development and tumorigenesis
AU - Madugula, Kiran
AU - Mulherkar, Ria
AU - Khan, Zafar K.
AU - Chigbu, De Gaulle I.
AU - Patel, Dip
AU - Harhaj, Edward W.
AU - Jain, Pooja
N1 - Publisher Copyright:
© 2019 Impact Journals LLC. All Rights Reserved.
PY - 2019/4/12
Y1 - 2019/4/12
N2 - Myocyte enhancer factor (MEF)-2 plays a critical role in proliferation, differentiation, and development of various cell types in a tissue specific manner. Four isoforms of MEF-2 (A-D) differentially participate in controlling the cell fate during the developmental phases of cardiac, muscle, vascular, immune and skeletal systems. Through their associations with various cellular factors MEF-2 isoforms can trigger alterations in complex protein networks and modulate various stages of cellular differentiation, proliferation, survival and apoptosis. The role of the MEF-2 family of transcription factors in the development has been investigated in various cell types, and the evolving alterations in this family of transcription factors have resulted in a diverse and wide spectrum of disease phenotypes, ranging from cancer to infection. This review provides a comprehensive account on MEF-2 isoforms (A-D) from their respective localization, signaling, role in development and tumorigenesis as well as their association with histone deacetylases (HDACs), which can be exploited for therapeutic intervention.
AB - Myocyte enhancer factor (MEF)-2 plays a critical role in proliferation, differentiation, and development of various cell types in a tissue specific manner. Four isoforms of MEF-2 (A-D) differentially participate in controlling the cell fate during the developmental phases of cardiac, muscle, vascular, immune and skeletal systems. Through their associations with various cellular factors MEF-2 isoforms can trigger alterations in complex protein networks and modulate various stages of cellular differentiation, proliferation, survival and apoptosis. The role of the MEF-2 family of transcription factors in the development has been investigated in various cell types, and the evolving alterations in this family of transcription factors have resulted in a diverse and wide spectrum of disease phenotypes, ranging from cancer to infection. This review provides a comprehensive account on MEF-2 isoforms (A-D) from their respective localization, signaling, role in development and tumorigenesis as well as their association with histone deacetylases (HDACs), which can be exploited for therapeutic intervention.
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U2 - 10.18632/oncotarget.26763
DO - 10.18632/oncotarget.26763
M3 - Review article
C2 - 31105874
AN - SCOPUS:85064978539
SN - 1949-2553
VL - 10
SP - 2755
EP - 2787
JO - Oncotarget
JF - Oncotarget
IS - 28
ER -