TY - JOUR
T1 - Membrane technology for the purification of RNA and DNA therapeutics
AU - Javidanbardan, Amin
AU - Messerian, Kevork Oliver
AU - Zydney, Andrew L.
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2024/6
Y1 - 2024/6
N2 - Nucleic acid therapeutics have the potential to revolutionize the biopharmaceutical industry, providing highly effective vaccines and novel treatments for cancers and genetic disorders. The successful commercialization of these therapeutics will require development of manufacturing strategies specifically tailored to the purification of nucleic acids. Membrane technologies already play a critical role in the downstream processing of nucleic acid therapeutics, ranging from clarification to concentration to selective purification. This review provides an overview of how membrane systems are currently used for nucleic acid purification, while highlighting areas of future need and opportunity, including adoption of membranes in continuous bioprocessing.
AB - Nucleic acid therapeutics have the potential to revolutionize the biopharmaceutical industry, providing highly effective vaccines and novel treatments for cancers and genetic disorders. The successful commercialization of these therapeutics will require development of manufacturing strategies specifically tailored to the purification of nucleic acids. Membrane technologies already play a critical role in the downstream processing of nucleic acid therapeutics, ranging from clarification to concentration to selective purification. This review provides an overview of how membrane systems are currently used for nucleic acid purification, while highlighting areas of future need and opportunity, including adoption of membranes in continuous bioprocessing.
UR - http://www.scopus.com/inward/record.url?scp=85183606228&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85183606228&partnerID=8YFLogxK
U2 - 10.1016/j.tibtech.2023.11.016
DO - 10.1016/j.tibtech.2023.11.016
M3 - Review article
C2 - 38212210
AN - SCOPUS:85183606228
SN - 0167-7799
VL - 42
SP - 714
EP - 727
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 6
ER -
