Membrane technology for the purification of RNA and DNA therapeutics

Amin Javidanbardan, Kevork Oliver Messerian, Andrew L. Zydney

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Nucleic acid therapeutics have the potential to revolutionize the biopharmaceutical industry, providing highly effective vaccines and novel treatments for cancers and genetic disorders. The successful commercialization of these therapeutics will require development of manufacturing strategies specifically tailored to the purification of nucleic acids. Membrane technologies already play a critical role in the downstream processing of nucleic acid therapeutics, ranging from clarification to concentration to selective purification. This review provides an overview of how membrane systems are currently used for nucleic acid purification, while highlighting areas of future need and opportunity, including adoption of membranes in continuous bioprocessing.

Original languageEnglish (US)
Pages (from-to)714-727
Number of pages14
JournalTrends in Biotechnology
Volume42
Issue number6
DOIs
StatePublished - Jun 2024

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering

Cite this