Memory booster plant Bacopa monniera (brahmi): Biotechnology and molecular aspects of bacoside biosynthesis

Rishi K. Vishwakarma, Uma Kumari, Bashir M. Khan

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


Bacopa monniera (Brahmi) has been used in the Ayurvedic system of medicine as a brain tonic, memory enhancer, antianxiety, cardiotonic, anticancer, anti-inflammatory, analgesic, and anticonvulsant agent since ancient times. These pharmacological properties are mainly attributed to the triterpenoid saponins present in the extracts of the plant. Biosynthesis of triterpenoid saponins starts from the isoprenoid pathway through farnesyl pyrophosphate by cyclization of 2,3-oxidosqualene, resulting in the formation of triterpenoid backbones. The plant produces relatively smaller amounts of bacosides, and to overcome this shortage, a large amount of biomass is used in the pharmaceutical preparations. Despite a wealth of medicinal importance, the molecular characterization and pathway engineering of bacoside biosynthesis in Bacopa remain unexplored. In this chapter, we have briefly discussed the research findings on in vitro plant regeneration, genetic transformation, and molecular characterization of some of the genes involved in the biosynthesis of bacosides.

Original languageEnglish (US)
Title of host publicationMedicinal Plants - Recent Advances in Research and Development
PublisherSpringer Singapore
Number of pages23
ISBN (Electronic)9789811010859
ISBN (Print)9789811010842
StatePublished - Jan 1 2016

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • General Medicine


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