TY - JOUR
T1 - Memristive Ion Channel-Doped Biomembranes as Synaptic Mimics
AU - Najem, Joseph S.
AU - Taylor, Graham J.
AU - Weiss, Ryan J.
AU - Hasan, Md Sakib
AU - Rose, Garrett
AU - Schuman, Catherine D.
AU - Belianinov, Alex
AU - Collier, C. Patrick
AU - Sarles, Stephen A.
N1 - Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/5/22
Y1 - 2018/5/22
N2 - Solid-state neuromorphic systems based on transistors or memristors have yet to achieve the interconnectivity, performance, and energy efficiency of the brain due to excessive noise, undesirable material properties, and nonbiological switching mechanisms. Here we demonstrate that an alamethicin-doped, synthetic biomembrane exhibits memristive behavior, emulates key synaptic functions including paired-pulse facilitation and depression, and enables learning and computing. Unlike state-of-the-art devices, our two-terminal, biomolecular memristor features similar structure (biomembrane), switching mechanism (ion channels), and ionic transport modality as biological synapses while operating at considerably lower power. The reversible and volatile voltage-driven insertion of alamethicin peptides into an insulating lipid bilayer creates conductive pathways that exhibit pinched current-voltage hysteresis at potentials above their insertion threshold. Moreover, the synapse-like dynamic properties of the biomolecular memristor allow for simplified learning circuit implementations. Low-power memristive devices based on stimuli-responsive biomolecules represent a major advance toward implementation of full synaptic functionality in neuromorphic hardware.
AB - Solid-state neuromorphic systems based on transistors or memristors have yet to achieve the interconnectivity, performance, and energy efficiency of the brain due to excessive noise, undesirable material properties, and nonbiological switching mechanisms. Here we demonstrate that an alamethicin-doped, synthetic biomembrane exhibits memristive behavior, emulates key synaptic functions including paired-pulse facilitation and depression, and enables learning and computing. Unlike state-of-the-art devices, our two-terminal, biomolecular memristor features similar structure (biomembrane), switching mechanism (ion channels), and ionic transport modality as biological synapses while operating at considerably lower power. The reversible and volatile voltage-driven insertion of alamethicin peptides into an insulating lipid bilayer creates conductive pathways that exhibit pinched current-voltage hysteresis at potentials above their insertion threshold. Moreover, the synapse-like dynamic properties of the biomolecular memristor allow for simplified learning circuit implementations. Low-power memristive devices based on stimuli-responsive biomolecules represent a major advance toward implementation of full synaptic functionality in neuromorphic hardware.
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U2 - 10.1021/acsnano.8b01282
DO - 10.1021/acsnano.8b01282
M3 - Article
C2 - 29578693
AN - SCOPUS:85047429238
SN - 1936-0851
VL - 12
SP - 4702
EP - 4711
JO - ACS nano
JF - ACS nano
IS - 5
ER -