MEMS device integrated with vertically aligned carbon nanotubes for virus capture and detection

Yin Ting Yeh; Nestor Perea-Lopez; Yi Tang; Brian U. McKellar; Ramdane Harouaka; Huaguang Lu; Mauricio Terrones; Si Yang Zheng

doi:10.31438/trf.hh2014.5

MEMS device integrated with vertically aligned carbon nanotubes for virus capture and detection

Yin Ting Yeh, Nestor Perea-Lopez, Yi Tang, Brian U. McKellar, Ramdane Harouaka, Huaguang Lu, Mauricio Terrones, Si Yang Zheng

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Point-of-care virus diagnosis is highly desirable in worldwide infectious disease control. Here we report a hand-held device for capturing viruses by applying physical size based exclusion inside a point-of-care device integrated with vertically aligned carbon nanotube (VACNT) nanostructures to achieve label-free and high throughput virus capture. The microfluidic device is constructed from a VACNT channel wall synthesized bottom-up via chemical vapor deposition (CVD). The VACNT has ~117nm average gap size and ~97% porosity. By bonding with a polydimethylsiloxane (PDMS) cover sealing the top, the aqueous sample containing virus particles filter through the VACNT channel wall under negative pressure applied at the outlet end. We have demonstrated that the device is capable of filtering 50µL of PBS containing ~6.3×10⁴ counts of lentivirus particles in 10 minutes with 97% of capture efficiency, quantified by the cell infectious titration technique.

Original language	English (US)
Title of host publication	2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014
Editors	Mark G. Allen, Mehran Mehregany
Publisher	Transducer Research Foundation
Pages	17-20
Number of pages	4
ISBN (Electronic)	9781940470016
DOIs	https://doi.org/10.31438/trf.hh2014.5
State	Published - 2014
Event	2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014 - Hilton Head Island, United States Duration: Jun 8 2014 → Jun 12 2014

Publication series

Name	Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop

Conference

Conference	2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014
Country/Territory	United States
City	Hilton Head Island
Period	6/8/14 → 6/12/14

All Science Journal Classification (ASJC) codes

Control and Systems Engineering
Electrical and Electronic Engineering
Hardware and Architecture

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.31438/trf.hh2014.5

Cite this

Yeh, Y. T., Perea-Lopez, N., Tang, Y., McKellar, B. U., Harouaka, R., Lu, H., Terrones, M., & Zheng, S. Y. (2014). MEMS device integrated with vertically aligned carbon nanotubes for virus capture and detection. In M. G. Allen, & M. Mehregany (Eds.), 2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014 (pp. 17-20). (Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop). Transducer Research Foundation. https://doi.org/10.31438/trf.hh2014.5

Yeh, Yin Ting ; Perea-Lopez, Nestor ; Tang, Yi et al. / MEMS device integrated with vertically aligned carbon nanotubes for virus capture and detection. 2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014. editor / Mark G. Allen ; Mehran Mehregany. Transducer Research Foundation, 2014. pp. 17-20 (Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop).

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title = "MEMS device integrated with vertically aligned carbon nanotubes for virus capture and detection",

abstract = "Point-of-care virus diagnosis is highly desirable in worldwide infectious disease control. Here we report a hand-held device for capturing viruses by applying physical size based exclusion inside a point-of-care device integrated with vertically aligned carbon nanotube (VACNT) nanostructures to achieve label-free and high throughput virus capture. The microfluidic device is constructed from a VACNT channel wall synthesized bottom-up via chemical vapor deposition (CVD). The VACNT has ~117nm average gap size and ~97% porosity. By bonding with a polydimethylsiloxane (PDMS) cover sealing the top, the aqueous sample containing virus particles filter through the VACNT channel wall under negative pressure applied at the outlet end. We have demonstrated that the device is capable of filtering 50µL of PBS containing ~6.3×104 counts of lentivirus particles in 10 minutes with 97% of capture efficiency, quantified by the cell infectious titration technique.",

author = "Yeh, {Yin Ting} and Nestor Perea-Lopez and Yi Tang and McKellar, {Brian U.} and Ramdane Harouaka and Huaguang Lu and Mauricio Terrones and Zheng, {Si Yang}",

note = "Publisher Copyright: {\textcopyright} 2014TRF.; 2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014 ; Conference date: 08-06-2014 Through 12-06-2014",

year = "2014",

doi = "10.31438/trf.hh2014.5",

language = "English (US)",

series = "Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop",

publisher = "Transducer Research Foundation",

pages = "17--20",

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Yeh, YT , Perea-Lopez, N, Tang, Y, McKellar, BU, Harouaka, R, Lu, H, Terrones, M & Zheng, SY 2014, MEMS device integrated with vertically aligned carbon nanotubes for virus capture and detection. in MG Allen & M Mehregany (eds), 2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014. Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop, Transducer Research Foundation, pp. 17-20, 2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014, Hilton Head Island, United States, 6/8/14. https://doi.org/10.31438/trf.hh2014.5

MEMS device integrated with vertically aligned carbon nanotubes for virus capture and detection. / Yeh, Yin Ting ; Perea-Lopez, Nestor; Tang, Yi et al.
2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014. ed. / Mark G. Allen; Mehran Mehregany. Transducer Research Foundation, 2014. p. 17-20 (Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Yeh, Yin Ting

AU - Perea-Lopez, Nestor

AU - Tang, Yi

AU - McKellar, Brian U.

AU - Harouaka, Ramdane

AU - Lu, Huaguang

AU - Terrones, Mauricio

AU - Zheng, Si Yang

PY - 2014

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N2 - Point-of-care virus diagnosis is highly desirable in worldwide infectious disease control. Here we report a hand-held device for capturing viruses by applying physical size based exclusion inside a point-of-care device integrated with vertically aligned carbon nanotube (VACNT) nanostructures to achieve label-free and high throughput virus capture. The microfluidic device is constructed from a VACNT channel wall synthesized bottom-up via chemical vapor deposition (CVD). The VACNT has ~117nm average gap size and ~97% porosity. By bonding with a polydimethylsiloxane (PDMS) cover sealing the top, the aqueous sample containing virus particles filter through the VACNT channel wall under negative pressure applied at the outlet end. We have demonstrated that the device is capable of filtering 50µL of PBS containing ~6.3×104 counts of lentivirus particles in 10 minutes with 97% of capture efficiency, quantified by the cell infectious titration technique.

AB - Point-of-care virus diagnosis is highly desirable in worldwide infectious disease control. Here we report a hand-held device for capturing viruses by applying physical size based exclusion inside a point-of-care device integrated with vertically aligned carbon nanotube (VACNT) nanostructures to achieve label-free and high throughput virus capture. The microfluidic device is constructed from a VACNT channel wall synthesized bottom-up via chemical vapor deposition (CVD). The VACNT has ~117nm average gap size and ~97% porosity. By bonding with a polydimethylsiloxane (PDMS) cover sealing the top, the aqueous sample containing virus particles filter through the VACNT channel wall under negative pressure applied at the outlet end. We have demonstrated that the device is capable of filtering 50µL of PBS containing ~6.3×104 counts of lentivirus particles in 10 minutes with 97% of capture efficiency, quantified by the cell infectious titration technique.

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M3 - Conference contribution

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T3 - Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop

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ER -

Yeh YT , Perea-Lopez N, Tang Y, McKellar BU, Harouaka R, Lu H et al. MEMS device integrated with vertically aligned carbon nanotubes for virus capture and detection. In Allen MG, Mehregany M, editors, 2014 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2014. Transducer Research Foundation. 2014. p. 17-20. (Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop). doi: 10.31438/trf.hh2014.5

MEMS device integrated with vertically aligned carbon nanotubes for virus capture and detection

Abstract

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All Science Journal Classification (ASJC) codes

UN SDGs

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