TY - JOUR
T1 - Metabo-miR
T2 - miR-211 Regulates Mitochondrial Energy Metabolism in Vitiligo
AU - Spiegelman, Vladimir S.
AU - Elcheva, Irina A.
N1 - Publisher Copyright:
© 2017 The Authors
PY - 2017/9
Y1 - 2017/9
N2 - The study by Sahoo et al. established miR-211 as a critical regulator of cellular metabolism in vitiligo cells. miR-211, which is expressed from the transient receptor potential melastatin 1 intronic region, regulates oxidative phosphorylation and mitochondrial energy metabolism in vitiligo. Loss of miR-211 in melanocytes was shown to alter expression patterns of newly identified target genes, and those that regulate respiratory functions in melanocytes are among them. This study highlights the importance of miR-211 for the melanocyte biology and development of vitiligo.
AB - The study by Sahoo et al. established miR-211 as a critical regulator of cellular metabolism in vitiligo cells. miR-211, which is expressed from the transient receptor potential melastatin 1 intronic region, regulates oxidative phosphorylation and mitochondrial energy metabolism in vitiligo. Loss of miR-211 in melanocytes was shown to alter expression patterns of newly identified target genes, and those that regulate respiratory functions in melanocytes are among them. This study highlights the importance of miR-211 for the melanocyte biology and development of vitiligo.
UR - http://www.scopus.com/inward/record.url?scp=85028343013&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028343013&partnerID=8YFLogxK
U2 - 10.1016/j.jid.2017.06.012
DO - 10.1016/j.jid.2017.06.012
M3 - Comment/debate
C2 - 28843294
AN - SCOPUS:85028343013
SN - 0022-202X
VL - 137
SP - 1828
EP - 1830
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 9
ER -