The study by Sahoo et al. established miR-211 as a critical regulator of cellular metabolism in vitiligo cells. miR-211, which is expressed from the transient receptor potential melastatin 1 intronic region, regulates oxidative phosphorylation and mitochondrial energy metabolism in vitiligo. Loss of miR-211 in melanocytes was shown to alter expression patterns of newly identified target genes, and those that regulate respiratory functions in melanocytes are among them. This study highlights the importance of miR-211 for the melanocyte biology and development of vitiligo.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology