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Metabolism and DNA Binding of 2-Nitropyrene in the Rat
Pramod Upadhyaya
, Ajit K. Roy
, Peter P. Fu
, Karam El-Bayoumy
Penn State Cancer Institute
Cancer Institute, Mechanisms of Carcinogenesis
Penn State Center for Research on Tobacco and Health
Department of Molecular and Precision Medicine
Research output
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Contribution to journal
›
Article
›
peer-review
11
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Scopus citations
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Keyphrases
Metabolism
100%
DNA Binding
100%
1-Nitropyrene
100%
1-Aminopyrene
85%
Nitroarene Reduction
42%
Ambient Air
28%
Kidney
28%
Liver
28%
Feces
28%
Metabolic Pathway
28%
Pyrene
28%
Nitro
28%
Analytical Method
14%
F344 Rats
14%
Lung
14%
Mutagens
14%
Mass Spectra
14%
Human Exposure
14%
Leukemia-lymphoma
14%
Urinary Metabolites
14%
Mammary Tissue
14%
Sprague-Dawley Rats
14%
Glucuronide Conjugate
14%
Radioactivity
14%
Bladder
14%
Aromatic Hydrocarbons
14%
Hydrolysate
14%
Tumorigenic Activities
14%
Gavage
14%
Acetylated Derivative
14%
Total DNA
14%
Synthetic Standards
14%
UV Spectra
14%
High Performance Liquid Chromatography Analysis
14%
Chromatographic Retention
14%
Ames Assay
14%
Fecal Metabolites
14%
Pharmacology, Toxicology and Pharmaceutical Science
2 Nitropyrene
100%
Pyrene Derivative
28%
Carbon 14
14%
Mutagenic Agent
14%
Fischer 344 Rat
14%
Carcinogenesis
14%
Leukemia
14%
Glucuronide
14%
Acetic Acid Derivative
14%
Sprague Dawley Rat
14%
Aromatic Hydrocarbon
14%