Abstract
The metabolism of O6-propyl-carbovir and N6-propyl-carbovir, two selective inhibitors of HIV replication, has been evaluated in CEM cells. Both compounds were phosphorylated in intact cells to carbovir-5'- triphosphate. The metabolism of these two agents was inhibited by deoxycoformycin and mycophenolic acid, but not erythro-9-(2-hydroxy-3- nonyl)adenine. No evidence of the 5'-triphosphate of either compound was detected in CEM cells.
Original language | English (US) |
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Pages (from-to) | 795-804 |
Number of pages | 10 |
Journal | Nucleosides, Nucleotides and Nucleic Acids |
Volume | 19 |
Issue number | 4 |
DOIs | |
State | Published - 2000 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Genetics