Metabolite changes resulting from treatment in children with ADHD: A 1H-MRS study

Normand Carrey, Frank P. MacMaster, Joshua Fogel, Sandra Sparkes, Dan Waschbusch, Sara Sullivan, Mathias Schmidt

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Previously the authors noted an increase in glutamatergic tone in children with attention deficit hyperactivity disorder compared with age- and gender-matched control subjects. In this study they examine the effect of treatment on metabolite concentrations. Fourteen children with attention deficit hyperactivity disorder were investigated medication free and after treatment, using proton magnetic resonance spectroscopy. In the prefrontal cortex and striatum, metabolite peaks of N-acetyl-aspartate, glutamate/glutamine/γ-aminobutyric acid, creatine/phosphocreatine, and choline compounds were measured, and ratios of the peaks were calculated and compared before and after treatment. The glutamate/glutamine/γ-aminobutyric acid-to-creatine/phosphocreatine ratio decreased significantly in the striatum. No other metabolites demonstrated any change in response to medication. These findings suggest that glutamate may be involved in treatment response in attention deficit hyperactivity disorder, especially in the striatum.

Original languageEnglish (US)
Pages (from-to)218-221
Number of pages4
JournalClinical Neuropharmacology
Issue number4
StatePublished - Jul 2003

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)


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