TY - JOUR
T1 - Metabolite changes resulting from treatment in children with ADHD
T2 - A 1H-MRS study
AU - Carrey, Normand
AU - MacMaster, Frank P.
AU - Fogel, Joshua
AU - Sparkes, Sandra
AU - Waschbusch, Dan
AU - Sullivan, Sara
AU - Schmidt, Mathias
PY - 2003/7
Y1 - 2003/7
N2 - Previously the authors noted an increase in glutamatergic tone in children with attention deficit hyperactivity disorder compared with age- and gender-matched control subjects. In this study they examine the effect of treatment on metabolite concentrations. Fourteen children with attention deficit hyperactivity disorder were investigated medication free and after treatment, using proton magnetic resonance spectroscopy. In the prefrontal cortex and striatum, metabolite peaks of N-acetyl-aspartate, glutamate/glutamine/γ-aminobutyric acid, creatine/phosphocreatine, and choline compounds were measured, and ratios of the peaks were calculated and compared before and after treatment. The glutamate/glutamine/γ-aminobutyric acid-to-creatine/phosphocreatine ratio decreased significantly in the striatum. No other metabolites demonstrated any change in response to medication. These findings suggest that glutamate may be involved in treatment response in attention deficit hyperactivity disorder, especially in the striatum.
AB - Previously the authors noted an increase in glutamatergic tone in children with attention deficit hyperactivity disorder compared with age- and gender-matched control subjects. In this study they examine the effect of treatment on metabolite concentrations. Fourteen children with attention deficit hyperactivity disorder were investigated medication free and after treatment, using proton magnetic resonance spectroscopy. In the prefrontal cortex and striatum, metabolite peaks of N-acetyl-aspartate, glutamate/glutamine/γ-aminobutyric acid, creatine/phosphocreatine, and choline compounds were measured, and ratios of the peaks were calculated and compared before and after treatment. The glutamate/glutamine/γ-aminobutyric acid-to-creatine/phosphocreatine ratio decreased significantly in the striatum. No other metabolites demonstrated any change in response to medication. These findings suggest that glutamate may be involved in treatment response in attention deficit hyperactivity disorder, especially in the striatum.
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U2 - 10.1097/00002826-200307000-00013
DO - 10.1097/00002826-200307000-00013
M3 - Article
C2 - 12897644
AN - SCOPUS:0042635698
SN - 0362-5664
VL - 26
SP - 218
EP - 221
JO - Clinical Neuropharmacology
JF - Clinical Neuropharmacology
IS - 4
ER -