Metabolomics of sleep disorders in HIV: a narrative review

Purpose: Sleep disturbances are prevalent among patients with human immunodeficiency virus (HIV), even those who are being treated on antiretroviral therapy. It is important to understand the metabolomic mechanisms underlying sleep disturbances among people living with HIV (PLWH). Methods: A review of recent literature was performed to explore the use of metabolomics in understanding sleep among PLWH. Results: We found only two studies that used metabolomics to explore sleep health among PLWH. Conclusion: This paper reviews common sleep disorders in HIV, the existing metabolomic studies that may explain the relationship, and implications for future research. The use of metabolomics in exploring sleep disorders among PLWH will help to elucidate mechanistic links to improve patient outcomes.