TY - JOUR
T1 - Metabolomics Reveals that Dietary Ferulic Acid and Quercetin Modulate Metabolic Homeostasis in Rats
AU - Zhang, Limin
AU - Dong, Manyuan
AU - Xu, Guangyong
AU - Tian, Yuan
AU - Tang, Huiru
AU - Wang, Yulan
N1 - Funding Information:
This work was financially supported by National Key R&D Program of China (2017YFC0906800) and the National Natural Science Foundation of China (21577169 and 21635006).
Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/2/21
Y1 - 2018/2/21
N2 - Phenolic compounds ingestion has been shown to have potential preventive and therapeutic effects against various metabolic diseases such as obesity and cancer. To provide a better understanding of these potential benefit effects, we investigated the metabolic alterations in urine and feces of rat ingested ferulic acid (FA) and quercetin (Qu) using NMR-based metabolomics approach. Our results suggested that dietary FA and/or Qu significantly decreased short chain fatty acids and elevated oligosaccharides in the feces, implying that dietary FA and Qu may modulate gut microbial community with inhibition of bacterial fermentation of dietary fibers. We also found that dietary FA and/or Qu regulated several host metabolic pathways including TCA cycle and energy metabolism, bile acid, amino acid, and nucleic acid metabolism. These biological effects suggest that FA and Qu display outstanding bioavailability and bioactivity and could be used for treatment of some metabolic syndromes, such as inflammatory bowel diseases and obesity.
AB - Phenolic compounds ingestion has been shown to have potential preventive and therapeutic effects against various metabolic diseases such as obesity and cancer. To provide a better understanding of these potential benefit effects, we investigated the metabolic alterations in urine and feces of rat ingested ferulic acid (FA) and quercetin (Qu) using NMR-based metabolomics approach. Our results suggested that dietary FA and/or Qu significantly decreased short chain fatty acids and elevated oligosaccharides in the feces, implying that dietary FA and Qu may modulate gut microbial community with inhibition of bacterial fermentation of dietary fibers. We also found that dietary FA and/or Qu regulated several host metabolic pathways including TCA cycle and energy metabolism, bile acid, amino acid, and nucleic acid metabolism. These biological effects suggest that FA and Qu display outstanding bioavailability and bioactivity and could be used for treatment of some metabolic syndromes, such as inflammatory bowel diseases and obesity.
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U2 - 10.1021/acs.jafc.8b00054
DO - 10.1021/acs.jafc.8b00054
M3 - Article
C2 - 29359554
AN - SCOPUS:85042382009
SN - 0021-8561
VL - 66
SP - 1723
EP - 1731
JO - Journal of agricultural and food chemistry
JF - Journal of agricultural and food chemistry
IS - 7
ER -
