Metal Ion Catalysis of Phosphoryl Transfer from Phosphoenolpyruvate

S. J. Benkovic; K. J. Schray

doi:10.1021/bi00851a044

Metal Ion Catalysis of Phosphoryl Transfer from Phosphoenolpyruvate

S. J. Benkovic, K. J. Schray

Chemistry

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23 Scopus citations

Abstract

The catalytic effect of mercury(II) and a number of other metal ions on the hydrolysis of phosphoenolpyruvate and ethyl phosphoenolpyruvate has been investigated. The mechanisms of catalysis and their effect on the phosphorylating properties of these substrate have been determined via kinetic and product studies. The unusual properties of the mercury(II)-phosphoenolpyruvate reaction which proceeds via mercury(II) addition to the enol double bond and can lead to either phosphorylation of solvent or P_i release are discussed. The implications of these studies for the mechanism of the pyruvate kinase reaction are considered.

Original language	English (US)
Pages (from-to)	4097-4102
Number of pages	6
Journal	Biochemistry
Volume	7
Issue number	11
DOIs	https://doi.org/10.1021/bi00851a044
State	Published - Nov 1 1968

All Science Journal Classification (ASJC) codes

Biochemistry

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10.1021/bi00851a044

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abstract = "The catalytic effect of mercury(II) and a number of other metal ions on the hydrolysis of phosphoenolpyruvate and ethyl phosphoenolpyruvate has been investigated. The mechanisms of catalysis and their effect on the phosphorylating properties of these substrate have been determined via kinetic and product studies. The unusual properties of the mercury(II)-phosphoenolpyruvate reaction which proceeds via mercury(II) addition to the enol double bond and can lead to either phosphorylation of solvent or Pi release are discussed. The implications of these studies for the mechanism of the pyruvate kinase reaction are considered.",

author = "Benkovic, {S. J.} and Schray, {K. J.}",

year = "1968",

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language = "English (US)",

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T1 - Metal Ion Catalysis of Phosphoryl Transfer from Phosphoenolpyruvate

AU - Benkovic, S. J.

AU - Schray, K. J.

PY - 1968/11/1

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N2 - The catalytic effect of mercury(II) and a number of other metal ions on the hydrolysis of phosphoenolpyruvate and ethyl phosphoenolpyruvate has been investigated. The mechanisms of catalysis and their effect on the phosphorylating properties of these substrate have been determined via kinetic and product studies. The unusual properties of the mercury(II)-phosphoenolpyruvate reaction which proceeds via mercury(II) addition to the enol double bond and can lead to either phosphorylation of solvent or Pi release are discussed. The implications of these studies for the mechanism of the pyruvate kinase reaction are considered.

AB - The catalytic effect of mercury(II) and a number of other metal ions on the hydrolysis of phosphoenolpyruvate and ethyl phosphoenolpyruvate has been investigated. The mechanisms of catalysis and their effect on the phosphorylating properties of these substrate have been determined via kinetic and product studies. The unusual properties of the mercury(II)-phosphoenolpyruvate reaction which proceeds via mercury(II) addition to the enol double bond and can lead to either phosphorylation of solvent or Pi release are discussed. The implications of these studies for the mechanism of the pyruvate kinase reaction are considered.

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JO - Biochemistry

JF - Biochemistry

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ER -

Metal Ion Catalysis of Phosphoryl Transfer from Phosphoenolpyruvate

Abstract

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