Metallo-β-lactamase: Structure and mechanism

Zhigang Wang, Walter Fast, Ann M. Valentine, Stephen J. Benkovic

Research output: Contribution to journalReview articlepeer-review

278 Scopus citations


This past year has produced determinations of X-ray crystal structures for three metallo-β-lactamases and the elucidation of the catalytic mechanisms for a monozine and a dizinc enzyme. These advances shed light on how such a diverse group of enzymes are evolving to inactivate so efficiently a broad spectrum of β-lactam antibiotics.

Original languageEnglish (US)
Pages (from-to)614-622
Number of pages9
JournalCurrent Opinion in Chemical Biology
Issue number5
StatePublished - Oct 1 1999

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry


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