Methadone and brain development

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The effect of maternally administered methadone hydrochloride (5 mg/kg) on brain development of off-spring treated during gestation and/or lactation was studied in 21-day-old rats. Animals treated during gestation or lactation were the most severely affected, with reductions in brain weights (12% and 30%,respectively), and DNA values (50% and 34%, respectively) observed.

Original languageEnglish (US)
Pages (from-to)1486-1487
Number of pages2
Issue number11
StatePublished - Nov 1 1977

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)


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