Methionine restriction and cancer biology

Desiree Wanders; Katherine Hobson; Xiangming Ji

doi:10.3390/nu12030684

Methionine restriction and cancer biology

Desiree Wanders, Katherine Hobson, Xiangming Ji

Nutritional Sciences

Research output: Contribution to journal › Review article › peer-review

132 Scopus citations

Abstract

The essential amino acid, methionine, is important for cancer cell growth and metabolism. A growing body of evidence indicates that methionine restriction inhibits cancer cell growth and may enhance the efficacy of chemotherapeutic agents. This review summarizes the efficacy and mechanism of action of methionine restriction on hallmarks of cancer in vitro and in vivo. The review highlights the role of glutathione formation, polyamine synthesis, and methyl group donation as mediators of the effects of methionine restriction on cancer biology. The translational potential of the use of methionine restriction as a personalized nutritional approach for the treatment of patients with cancer is also discussed.

Original language	English (US)
Article number	684
Journal	Nutrients
Volume	12
Issue number	3
DOIs	https://doi.org/10.3390/nu12030684
State	Published - Mar 2020

All Science Journal Classification (ASJC) codes

Food Science
Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/nu12030684

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title = "Methionine restriction and cancer biology",

abstract = "The essential amino acid, methionine, is important for cancer cell growth and metabolism. A growing body of evidence indicates that methionine restriction inhibits cancer cell growth and may enhance the efficacy of chemotherapeutic agents. This review summarizes the efficacy and mechanism of action of methionine restriction on hallmarks of cancer in vitro and in vivo. The review highlights the role of glutathione formation, polyamine synthesis, and methyl group donation as mediators of the effects of methionine restriction on cancer biology. The translational potential of the use of methionine restriction as a personalized nutritional approach for the treatment of patients with cancer is also discussed.",

author = "Desiree Wanders and Katherine Hobson and Xiangming Ji",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = mar,

doi = "10.3390/nu12030684",

language = "English (US)",

volume = "12",

journal = "Nutrients",

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T1 - Methionine restriction and cancer biology

AU - Wanders, Desiree

AU - Hobson, Katherine

AU - Ji, Xiangming

PY - 2020/3

Y1 - 2020/3

N2 - The essential amino acid, methionine, is important for cancer cell growth and metabolism. A growing body of evidence indicates that methionine restriction inhibits cancer cell growth and may enhance the efficacy of chemotherapeutic agents. This review summarizes the efficacy and mechanism of action of methionine restriction on hallmarks of cancer in vitro and in vivo. The review highlights the role of glutathione formation, polyamine synthesis, and methyl group donation as mediators of the effects of methionine restriction on cancer biology. The translational potential of the use of methionine restriction as a personalized nutritional approach for the treatment of patients with cancer is also discussed.

AB - The essential amino acid, methionine, is important for cancer cell growth and metabolism. A growing body of evidence indicates that methionine restriction inhibits cancer cell growth and may enhance the efficacy of chemotherapeutic agents. This review summarizes the efficacy and mechanism of action of methionine restriction on hallmarks of cancer in vitro and in vivo. The review highlights the role of glutathione formation, polyamine synthesis, and methyl group donation as mediators of the effects of methionine restriction on cancer biology. The translational potential of the use of methionine restriction as a personalized nutritional approach for the treatment of patients with cancer is also discussed.

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VL - 12

JO - Nutrients

JF - Nutrients

IS - 3

M1 - 684

ER -

Methionine restriction and cancer biology

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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