Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937

Keyphrases

• Interleukin-1β 100%
• Interleukin-6 100%
• Methotrexate 100%
• Monocytic Cells 100%
• U937 100%
• C-Jun N-terminal Kinase 27%
• U937 Cells 27%
• Rheumatoid Arthritis 18%
• Observed Effects 18%
• Gene Expression 9%
• Tumor Necrosis Factor-α 9%
• Secreted Proteins 9%
• Dose Effect 9%
• Mechanism of Action 9%
• JNK2 9%
• Nuclear factor-κB 9%
• Inflammatory Cytokines 9%
• Pharmacologic 9%
• Malignancy 9%
• Kinase Cascade 9%
• Pneumonitis 9%
• Immune Function 9%
• Folate 9%
• Theophylline 9%
• Adenosine 9%
• Human Monocytic Cell Line 9%
• Cytokine Expression 9%
• Caffeine 9%
• Changes in Gene Expression 9%
• Decreased Bone Density 9%
• Anti-inflammatory Effect 9%
• Mucositis 9%

Immunology and Microbiology

• Cell Line 100%
• Interleukin 1 100%
• Interleukin 6 100%
• Methotrexate 100%
• Amino Terminal Sequence 27%
• Inflammatory Arthritis 18%
• Gene Expression 18%
• Cytokine 18%
• Signal Transduction 9%
• Proinflammatory Cytokine 9%
• Pneumonitis 9%
• Theophylline 9%
• Bone Density 9%
• Tumor Necrosis Factor Alpha 9%
• Antiinflammatory Activity 9%

Pharmacology, Toxicology and Pharmaceutical Science

• Interleukin 1 100%
• Interleukin 6 100%
• Methotrexate 100%
• Phosphotransferase 27%
• Cytokine 27%
• Adenosine 18%
• Rheumatoid Arthritis 18%
• Folic Acid 18%
• Disease 9%
• Tumor Necrosis Factor 9%
• Pneumonia 9%
• Theophylline 9%
• Antiinflammatory Activity 9%
• Mucosa Inflammation 9%