Methotrexate sodium-associated uv reactivation in a patient with acute lymphoblastic leukemia

Jessica Yankura, Nicole Saddic, Christopher R. Jones, David R. Adams

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


UV reactivation is an uncommon reaction characterized by recurrent inflammation in areas of prior sunburn or UV exposure following the administration of a triggering drug. We report a case of UV reactivation following administration of intravenous methotrexate sodium (MTX) 4 days after prolonged sun exposure in a 9-year-old boy with relapsed acute lymphoblastic leukemia. Our patient's MTX-associated UV reactivation occurred despite the use of sunscreen and without prior sunburn or sun-induced erythema, which suggests that even subclinical sun damage can trigger MTX-associated UV reactivation. Therefore, patients must be strongly encouraged to utilize a 3-pronged approach to sun safety including sun avoidance, sun-protective clothing, and broad-spectrum sunscreen use, especially during the week before MTX therapy.

Original languageEnglish (US)
Pages (from-to)233-236
Number of pages4
Issue number5
StatePublished - May 2012

All Science Journal Classification (ASJC) codes

  • Dermatology


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