Methylchloroisothiazolinone/methylisothiazolinone (Kathon CG) biocide: Second United States multicenter study of human skin sensitization

James G. Marks, Jack N. Moss, Jeffrey R. Parno, Robert M. Adams, Donald V. Belsito, Vincent A. DeLeo, Anthony Fransway, Joseph F. Fowler, Howard I. Maibach, C. G. Toby Mathias, James R. Nethercott, Robert L. Rietschel, Elizabeth Sherertz, Frances J. Storrs, James S. Taylor

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Background: This is the second United States multicenter study of human skin sensitization to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI). From January 1991 through March 1992 patients treated in 11 patch test clinics were patch tested to 100 ppm MCI/MI, formaldehyde 1% aqueous, quaternium-15 2% petrolatum, imidazolidinyl urea 2% petrolatum, and paraben mix 12% petrolatum. Results: Twenty-three of the 1,259 patch test patients (1.8%) had positive patch test reactions to MCI/MI. Thirteen of the 23 (56.5%) were thought to be relevant to the presenting dermatitis. The frequency of positive patch test reactions to the other allergens was quaternium-15, 7.2%; formaldehyde, 7.1%; imidazolidinyl urea, 2.2%; and paraben mix, 1.4%. Conclusion: Skin sensitization to MCI/MI has not changed significantly since the first United States multicenter study in 1988 to 1989. The rate of positive patch test responses to MCI/MI was comparable with that for parabens and imidazolidinyl urea and significantly less than for formaldehyde and quaternium-15.

Original languageEnglish (US)
Pages (from-to)87-89
Number of pages3
JournalAmerican Journal of Contact Dermatitis
Issue number2
StatePublished - Jun 1993

All Science Journal Classification (ASJC) codes

  • Dermatology


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