Methylseleninic acid elevates REDD1 and inhibits prostate cancer cell growth despite AKT activation and mTOR dysregulation in hypoxia

Keyphrases

• Dysregulation 100%
• Mammalian Target of Rapamycin (mTOR) 100%
• Methylseleninic Acid 100%
• Prostate Cancer Cells 100%
• Hypoxia 100%
• Cancer Cell Growth 100%
• Akt Activation 100%
• REDD+ 100%
• MTOR Inhibitor 25%
• Acid Activation 12%
• P70S6K 12%
• Cell Proliferation 12%
• Cell Death 12%
• Akt Phosphorylation 12%
• Lyase 12%
• Antitumor Activity 12%
• Induced Growth 12%
• Partial Resistance 12%
• Growth Reduction 12%
• Selenium Metabolites 12%
• Methylselenocysteine 12%
• Promote Apoptosis 12%

Medicine and Dentistry

• Prostate Cancer 100%
• Cancer Growth 100%
• Mammalian Target of Rapamycin 100%
• Hypoxia 100%
• Cancer Cell 66%
• Malignant Neoplasm 16%
• Metabolite 16%
• Cell Death 16%
• Cell Proliferation 16%
• Antineoplastic Activity 16%
• Programmed Cell Death 16%
• Mammalian Target of Rapamycin Inhibitor 16%
• Hypoxia Inducible Factor 16%
• Transamination 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Prostate Cancer 100%
• Cancer Growth 100%
• Hypoxia 100%
• Malignant Neoplasm 16%
• Lyase 16%
• Antitumor Activity 16%
• Mammalian Target of Rapamycin Inhibitor 16%
• Hypoxia Inducible Factor 16%