Mhc restriction and Ir genes

Jan Klein, Zoltan A. Nagy

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


There are two kinds of Mhc molecules, prosaically referred to as class I and class II. Mhc in mouse is called “H-2” and is known to consist of at least three class I loci—namely, K, D, and L and four class II loci: Aα, and Aβ, the products of which come together in the membrane as Aα,Aβ, dimers or the A molecule; and Eα, and Eβ, the products of which form the membrane EαEβ dimers or the E molecule. Mhc can stimulate every conceivable form of immune response: the Mhc molecules easily induce antibody formation, they stimulate T cells in mixed lymphocyte culture as no other membrane molecules do. They are superb targets in cell-mediated lymphocytotoxicity, they initiate violent allograft rejection, and they elicit graft-versus-host reactions, immunological tolerance, delayed-type hypersensitivity reactions, and other responses. Furthermore, the chapter illustrates the reason for the H-2 molecules being such good antigens in so many immunological assays.

Original languageEnglish (US)
Pages (from-to)233-317
Number of pages85
JournalAdvances in Cancer Research
Issue numberC
StatePublished - Jan 1 1982

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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