TY - JOUR
T1 - Mhc restriction and Ir genes
AU - Klein, Jan
AU - Nagy, Zoltan A.
N1 - Funding Information:
We thank Ms. Rosemary Franklin and Ms. Karina Masur for help in preparing this manuscript. The work was supported in part by a grant from the Deutsche Forschungsgemeinschaft.
PY - 1982/1/1
Y1 - 1982/1/1
N2 - There are two kinds of Mhc molecules, prosaically referred to as class I and class II. Mhc in mouse is called “H-2” and is known to consist of at least three class I loci—namely, K, D, and L and four class II loci: Aα, and Aβ, the products of which come together in the membrane as Aα,Aβ, dimers or the A molecule; and Eα, and Eβ, the products of which form the membrane EαEβ dimers or the E molecule. Mhc can stimulate every conceivable form of immune response: the Mhc molecules easily induce antibody formation, they stimulate T cells in mixed lymphocyte culture as no other membrane molecules do. They are superb targets in cell-mediated lymphocytotoxicity, they initiate violent allograft rejection, and they elicit graft-versus-host reactions, immunological tolerance, delayed-type hypersensitivity reactions, and other responses. Furthermore, the chapter illustrates the reason for the H-2 molecules being such good antigens in so many immunological assays.
AB - There are two kinds of Mhc molecules, prosaically referred to as class I and class II. Mhc in mouse is called “H-2” and is known to consist of at least three class I loci—namely, K, D, and L and four class II loci: Aα, and Aβ, the products of which come together in the membrane as Aα,Aβ, dimers or the A molecule; and Eα, and Eβ, the products of which form the membrane EαEβ dimers or the E molecule. Mhc can stimulate every conceivable form of immune response: the Mhc molecules easily induce antibody formation, they stimulate T cells in mixed lymphocyte culture as no other membrane molecules do. They are superb targets in cell-mediated lymphocytotoxicity, they initiate violent allograft rejection, and they elicit graft-versus-host reactions, immunological tolerance, delayed-type hypersensitivity reactions, and other responses. Furthermore, the chapter illustrates the reason for the H-2 molecules being such good antigens in so many immunological assays.
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U2 - 10.1016/S0065-230X(08)60885-4
DO - 10.1016/S0065-230X(08)60885-4
M3 - Article
C2 - 6222631
AN - SCOPUS:0020437137
SN - 0065-230X
VL - 37
SP - 233
EP - 317
JO - Advances in Cancer Research
JF - Advances in Cancer Research
IS - C
ER -