Microbleed prevalence and burden in anticoagulant-associated intracerebral bleed

Vasileios Arsenios Lioutas, Nitin Goyal, Aristeidis H. Katsanos, Christos Krogias, Ramin Zand, Vijay K. Sharma, Panayiotis Varelas, Konark Malhotra, Maurizio Paciaroni, Aboubakar Sharaf, Jason Chang, Odysseas Kargiotis, Abhi Pandhi, Christoph Schroeder, Argyrios Tsantes, Efstathios Boviatsis, Chandan Mehta, Panayiotis D. Mitsias, Magdy H. Selim, Andrei V. AlexandrovGeorgios Tsivgoulis

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Prior studies suggest an association between Vitamin K antagonists (VKA) and cerebral microbleeds (CMBs); less is known about nonvitamin K oral anticoagulants (NOACs). In this observational study we describe CMB profiles in a multicenter cohort of 89 anticoagulation-related intracerebral hemorrhage (ICH) patients. CMB prevalence was 51% (52% in VKA-ICH, 48% in NOAC-ICH). NOAC-ICH patients had lower median CMB count [2(IQR:1–3) vs. 7(4–11); P < 0.001]; ≥5 CMBs were less prevalent in NOAC-ICH (4% vs. 31%, P = 0.006). This inverse association between NOAC exposure and high CMB count persisted in multivariable logistic regression models adjusting for potential confounders (OR 0.10, 95%CI: 0.01–0.83; P = 0.034).

Original languageEnglish (US)
Pages (from-to)1546-1551
Number of pages6
JournalAnnals of Clinical and Translational Neurology
Issue number8
StatePublished - 2019

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • Clinical Neurology


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