Microbleed prevalence and burden in anticoagulant-associated intracerebral bleed

Vasileios Arsenios Lioutas; Nitin Goyal; Aristeidis H. Katsanos; Christos Krogias; Ramin Zand; Vijay K. Sharma; Panayiotis Varelas; Konark Malhotra; Maurizio Paciaroni; Aboubakar Sharaf; Jason Chang; Odysseas Kargiotis; Abhi Pandhi; Christoph Schroeder; Argyrios Tsantes; Efstathios Boviatsis; Chandan Mehta; Panayiotis D. Mitsias; Magdy H. Selim; Andrei V. Alexandrov; Georgios Tsivgoulis

doi:10.1002/acn3.50834

Microbleed prevalence and burden in anticoagulant-associated intracerebral bleed

Vasileios Arsenios Lioutas, Nitin Goyal, Aristeidis H. Katsanos, Christos Krogias, Ramin Zand, Vijay K. Sharma, Panayiotis Varelas, Konark Malhotra, Maurizio Paciaroni, Aboubakar Sharaf, Jason Chang, Odysseas Kargiotis, Abhi Pandhi, Christoph Schroeder, Argyrios Tsantes, Efstathios Boviatsis, Chandan Mehta, Panayiotis D. Mitsias, Magdy H. Selim, Andrei V. AlexandrovGeorgios Tsivgoulis

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Abstract

Prior studies suggest an association between Vitamin K antagonists (VKA) and cerebral microbleeds (CMBs); less is known about nonvitamin K oral anticoagulants (NOACs). In this observational study we describe CMB profiles in a multicenter cohort of 89 anticoagulation-related intracerebral hemorrhage (ICH) patients. CMB prevalence was 51% (52% in VKA-ICH, 48% in NOAC-ICH). NOAC-ICH patients had lower median CMB count [2(IQR:1–3) vs. 7(4–11); P < 0.001]; ≥5 CMBs were less prevalent in NOAC-ICH (4% vs. 31%, P = 0.006). This inverse association between NOAC exposure and high CMB count persisted in multivariable logistic regression models adjusting for potential confounders (OR 0.10, 95%CI: 0.01–0.83; P = 0.034).

Original language	English (US)
Pages (from-to)	1546-1551
Number of pages	6
Journal	Annals of Clinical and Translational Neurology
Volume	6
Issue number	8
DOIs	https://doi.org/10.1002/acn3.50834
State	Published - 2019

All Science Journal Classification (ASJC) codes

General Neuroscience
Clinical Neurology

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Lioutas, V. A., Goyal, N., Katsanos, A. H., Krogias, C., Zand, R., Sharma, V. K., Varelas, P., Malhotra, K., Paciaroni, M., Sharaf, A., Chang, J., Kargiotis, O., Pandhi, A., Schroeder, C., Tsantes, A., Boviatsis, E., Mehta, C., Mitsias, P. D., Selim, M. H., ... Tsivgoulis, G. (2019). Microbleed prevalence and burden in anticoagulant-associated intracerebral bleed. Annals of Clinical and Translational Neurology, 6(8), 1546-1551. https://doi.org/10.1002/acn3.50834

@article{ea14205de0144ee8b2f2cb714a333120,

title = "Microbleed prevalence and burden in anticoagulant-associated intracerebral bleed",

abstract = "Prior studies suggest an association between Vitamin K antagonists (VKA) and cerebral microbleeds (CMBs); less is known about nonvitamin K oral anticoagulants (NOACs). In this observational study we describe CMB profiles in a multicenter cohort of 89 anticoagulation-related intracerebral hemorrhage (ICH) patients. CMB prevalence was 51% (52% in VKA-ICH, 48% in NOAC-ICH). NOAC-ICH patients had lower median CMB count [2(IQR:1–3) vs. 7(4–11); P < 0.001]; ≥5 CMBs were less prevalent in NOAC-ICH (4% vs. 31%, P = 0.006). This inverse association between NOAC exposure and high CMB count persisted in multivariable logistic regression models adjusting for potential confounders (OR 0.10, 95%CI: 0.01–0.83; P = 0.034).",

author = "Lioutas, {Vasileios Arsenios} and Nitin Goyal and Katsanos, {Aristeidis H.} and Christos Krogias and Ramin Zand and Sharma, {Vijay K.} and Panayiotis Varelas and Konark Malhotra and Maurizio Paciaroni and Aboubakar Sharaf and Jason Chang and Odysseas Kargiotis and Abhi Pandhi and Christoph Schroeder and Argyrios Tsantes and Efstathios Boviatsis and Chandan Mehta and Mitsias, {Panayiotis D.} and Selim, {Magdy H.} and Alexandrov, {Andrei V.} and Georgios Tsivgoulis",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.",

year = "2019",

doi = "10.1002/acn3.50834",

language = "English (US)",

volume = "6",

pages = "1546--1551",

journal = "Annals of Clinical and Translational Neurology",

issn = "2328-9503",

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Lioutas, VA, Goyal, N, Katsanos, AH, Krogias, C, Zand, R, Sharma, VK, Varelas, P, Malhotra, K, Paciaroni, M, Sharaf, A, Chang, J, Kargiotis, O, Pandhi, A, Schroeder, C, Tsantes, A, Boviatsis, E, Mehta, C, Mitsias, PD, Selim, MH, Alexandrov, AV & Tsivgoulis, G 2019, 'Microbleed prevalence and burden in anticoagulant-associated intracerebral bleed', Annals of Clinical and Translational Neurology, vol. 6, no. 8, pp. 1546-1551. https://doi.org/10.1002/acn3.50834

TY - JOUR

T1 - Microbleed prevalence and burden in anticoagulant-associated intracerebral bleed

AU - Lioutas, Vasileios Arsenios

AU - Goyal, Nitin

AU - Katsanos, Aristeidis H.

AU - Krogias, Christos

AU - Zand, Ramin

AU - Sharma, Vijay K.

AU - Varelas, Panayiotis

AU - Malhotra, Konark

AU - Paciaroni, Maurizio

AU - Sharaf, Aboubakar

AU - Chang, Jason

AU - Kargiotis, Odysseas

AU - Pandhi, Abhi

AU - Schroeder, Christoph

AU - Tsantes, Argyrios

AU - Boviatsis, Efstathios

AU - Mehta, Chandan

AU - Mitsias, Panayiotis D.

AU - Selim, Magdy H.

AU - Alexandrov, Andrei V.

AU - Tsivgoulis, Georgios

PY - 2019

Y1 - 2019

N2 - Prior studies suggest an association between Vitamin K antagonists (VKA) and cerebral microbleeds (CMBs); less is known about nonvitamin K oral anticoagulants (NOACs). In this observational study we describe CMB profiles in a multicenter cohort of 89 anticoagulation-related intracerebral hemorrhage (ICH) patients. CMB prevalence was 51% (52% in VKA-ICH, 48% in NOAC-ICH). NOAC-ICH patients had lower median CMB count [2(IQR:1–3) vs. 7(4–11); P < 0.001]; ≥5 CMBs were less prevalent in NOAC-ICH (4% vs. 31%, P = 0.006). This inverse association between NOAC exposure and high CMB count persisted in multivariable logistic regression models adjusting for potential confounders (OR 0.10, 95%CI: 0.01–0.83; P = 0.034).

AB - Prior studies suggest an association between Vitamin K antagonists (VKA) and cerebral microbleeds (CMBs); less is known about nonvitamin K oral anticoagulants (NOACs). In this observational study we describe CMB profiles in a multicenter cohort of 89 anticoagulation-related intracerebral hemorrhage (ICH) patients. CMB prevalence was 51% (52% in VKA-ICH, 48% in NOAC-ICH). NOAC-ICH patients had lower median CMB count [2(IQR:1–3) vs. 7(4–11); P < 0.001]; ≥5 CMBs were less prevalent in NOAC-ICH (4% vs. 31%, P = 0.006). This inverse association between NOAC exposure and high CMB count persisted in multivariable logistic regression models adjusting for potential confounders (OR 0.10, 95%CI: 0.01–0.83; P = 0.034).

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U2 - 10.1002/acn3.50834

DO - 10.1002/acn3.50834

M3 - Article

C2 - 31402613

AN - SCOPUS:85068726399

SN - 2328-9503

VL - 6

SP - 1546

EP - 1551

JO - Annals of Clinical and Translational Neurology

JF - Annals of Clinical and Translational Neurology

IS - 8

ER -

Microbleed prevalence and burden in anticoagulant-associated intracerebral bleed

Abstract

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