TY - JOUR
T1 - Microcystin-lr decreases hepatic and renal perfusion, and causes circulatory shock, severe hypoglycemia, and terminal hyperkalemia in intravascularly dosed swine
AU - Beasley, Val R.
AU - Lovell, Randall A.
AU - Holmes, Kenneth R.
AU - Walcott, Horace E.
AU - Schaeffer, David J.
AU - Hoffmann, Walter E.
AU - Carmichael, Wayne W.
N1 - Funding Information:
The authors gratefully acknowledge the technical assistance and effort of Richard K. Manuel, Joni Dye, John Scott, and Billy Moore. These studies were supported in part by the U.S. Army Medical Research and Development Command contract 17-85-C-5241, and NIH-NHLBI grant number HL-27011. The views, opinions, and findings contained in this report are those of the authors and should not be construed as an official Department of the Army position, policy, or decision unless so designated by other documentation.
PY - 2000
Y1 - 2000
N2 - Cross-bred, anesthetized female swine were given intravascularly a lethal (72 µg/kg; n = 6) or toxic-sublethal (25 µg/kg; n = 6) dose of microcystin-LR (MCLR), from Microcystis aeruginosa, or the vehicle (n = 4). At the high dose, from 12 to 18 min after administration, central venous pressure and hepatic perfusion were significantly lower, and shortly thereafter, portal venous pressure was significantly higher and aortic mean pressure was significantly lower than controls. By 45 min postdosing, serum bile acids, lactate, potassium, and total bilirubin, as well as blood pO2, were significantly higher, while hematocrit, platelet count, and blood bicarbonate, pCO2, and base excess were significantly lower than controls. By 90 min, serum arginase, urea nitrogen, inorganic phosphorus, and creatinine were significantly higher, while glucose and blood pH were significantly.
AB - Cross-bred, anesthetized female swine were given intravascularly a lethal (72 µg/kg; n = 6) or toxic-sublethal (25 µg/kg; n = 6) dose of microcystin-LR (MCLR), from Microcystis aeruginosa, or the vehicle (n = 4). At the high dose, from 12 to 18 min after administration, central venous pressure and hepatic perfusion were significantly lower, and shortly thereafter, portal venous pressure was significantly higher and aortic mean pressure was significantly lower than controls. By 45 min postdosing, serum bile acids, lactate, potassium, and total bilirubin, as well as blood pO2, were significantly higher, while hematocrit, platelet count, and blood bicarbonate, pCO2, and base excess were significantly lower than controls. By 90 min, serum arginase, urea nitrogen, inorganic phosphorus, and creatinine were significantly higher, while glucose and blood pH were significantly.
UR - http://www.scopus.com/inward/record.url?scp=0034722018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034722018&partnerID=8YFLogxK
U2 - 10.1080/00984100050136599
DO - 10.1080/00984100050136599
M3 - Article
C2 - 11071321
AN - SCOPUS:0034722018
SN - 1528-7394
VL - 61
SP - 281
EP - 303
JO - Journal of Toxicology and Environmental Health - Part A
JF - Journal of Toxicology and Environmental Health - Part A
IS - 4
ER -