TY - JOUR
T1 - Microencapsulation of chemotherapeutics into monodisperse and tunable biodegradable polymers via electrified liquid jets
T2 - Control of size, shape, and drug release
AU - Fattahi, Pouria
AU - Borhan, Ali
AU - Abidian, Mohammad Reza
PY - 2013/9/6
Y1 - 2013/9/6
N2 - This paper describes microencapsulation of antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, Carmustine) into biodegradable polymer poly(lactic-co-glycolic) acid (PLGA) using an electrojetting technique. The resulting BCNU-loaded PLGA microcapsules have significantly higher drug encapsulation efficiency, more tunable drug loading capacity, and (3) narrower size distribution than those generated using other encapsulation methods.
AB - This paper describes microencapsulation of antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, Carmustine) into biodegradable polymer poly(lactic-co-glycolic) acid (PLGA) using an electrojetting technique. The resulting BCNU-loaded PLGA microcapsules have significantly higher drug encapsulation efficiency, more tunable drug loading capacity, and (3) narrower size distribution than those generated using other encapsulation methods.
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U2 - 10.1002/adma.201301033
DO - 10.1002/adma.201301033
M3 - Article
C2 - 23824544
AN - SCOPUS:84883489542
SN - 0935-9648
VL - 25
SP - 4555
EP - 4560
JO - Advanced Materials
JF - Advanced Materials
IS - 33
ER -