TY - GEN
T1 - Microfiltration device for continuous, label-free bacteria separation from whole blood for sepsis treatment
AU - Aran, Kiana
AU - Morales, Mercedes
AU - Sasso, Lawrence A.
AU - Lo, Jean
AU - Zheng, Mingde
AU - Johnston, Ian
AU - Kamdar, Neal
AU - Ündar, Akif
AU - Zahn, Jeffrey D.
PY - 2011
Y1 - 2011
N2 - This work presents the design, fabrication, and testing of a cross-flow filtration microdevice, for the continuous extraction of bacteria from a whole blood sample for the treatment of sepsis and bacteremia. The system consists of a two-compartment microdevice with two aligned sets of PDMS microchannels, separated by a porous polycarbonate (PCTE) membrane with 2 μm pores. When a whole blood sample flows through the channels on one side of the membrane (Reservoir channels), the larger blood cells are sterically excluded from passing through the membrane while the smaller bacteria are removed by traversing the membrane into the filtration channels.
AB - This work presents the design, fabrication, and testing of a cross-flow filtration microdevice, for the continuous extraction of bacteria from a whole blood sample for the treatment of sepsis and bacteremia. The system consists of a two-compartment microdevice with two aligned sets of PDMS microchannels, separated by a porous polycarbonate (PCTE) membrane with 2 μm pores. When a whole blood sample flows through the channels on one side of the membrane (Reservoir channels), the larger blood cells are sterically excluded from passing through the membrane while the smaller bacteria are removed by traversing the membrane into the filtration channels.
UR - http://www.scopus.com/inward/record.url?scp=84883815334&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883815334&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84883815334
SN - 9781618395955
T3 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
SP - 497
EP - 499
BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
T2 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Y2 - 2 October 2011 through 6 October 2011
ER -