TY - GEN
T1 - Microfluidic cell co-culture using standing surface acoustic wave (SSAW)
AU - Li, Sixing
AU - Guo, Feng
AU - Chen, Yuchao
AU - Ding, Xiaoyun
AU - Li, Peng
AU - Cameron, Craig E.
AU - Huang, Tony Jun
N1 - Publisher Copyright:
© 14CBMS.
PY - 2014
Y1 - 2014
N2 - The in vitro study of heterotypic cell-cell interactions requires co-culturing different types of cells in a highly controllable manner. In this work, we demonstrate a standing surface acoustic wave (SSAW)-based microfluidic device that is capable of patterning different types of cells sequentially in the generated SSAW field to form organized cell co-cultures. In our approach, non-invasive acoustic forces are utilized to manipulate cells in the SSAW field. The advantages of our SSAW-based microfluidic cell co-culture platform include contactless cell manipulation, simplicity, high biocompatibility, high resolution, and minimal interference of the cellular microenvironment. The microfluidic platform demonstrated here can be a valuable tool for studying cell-cell interactions and multicellular tissue reconstruction.
AB - The in vitro study of heterotypic cell-cell interactions requires co-culturing different types of cells in a highly controllable manner. In this work, we demonstrate a standing surface acoustic wave (SSAW)-based microfluidic device that is capable of patterning different types of cells sequentially in the generated SSAW field to form organized cell co-cultures. In our approach, non-invasive acoustic forces are utilized to manipulate cells in the SSAW field. The advantages of our SSAW-based microfluidic cell co-culture platform include contactless cell manipulation, simplicity, high biocompatibility, high resolution, and minimal interference of the cellular microenvironment. The microfluidic platform demonstrated here can be a valuable tool for studying cell-cell interactions and multicellular tissue reconstruction.
UR - http://www.scopus.com/inward/record.url?scp=84941637925&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941637925&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84941637925
T3 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
SP - 533
EP - 535
BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PB - Chemical and Biological Microsystems Society
T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Y2 - 26 October 2014 through 30 October 2014
ER -