Microfluidic platform with hierarchical micro/nanostructures and SELEX nucleic acid aptamer coating for isolation of circulating tumor cells

Vikhram V. Swaminathan; Spandana Gannavaram; Shihui Li; Huan Hu; Junghoon Yeom; Yong Wang; Likun Zhu

doi:10.1109/NANO.2013.6720968

Microfluidic platform with hierarchical micro/nanostructures and SELEX nucleic acid aptamer coating for isolation of circulating tumor cells

Vikhram V. Swaminathan, Spandana Gannavaram, Shihui Li, Huan Hu, Junghoon Yeom, Yong Wang, Likun Zhu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Microfluidic platforms provide elegant schemes for isolation of rare cells from the blood. Hierarchical 3-dimensional architectures with silicon nanopillar forests draw advantage of unique surface interactions with target cells to aid capture and adhesion. Microchannels with numerically optimized designs of micro post arrays maximize contact frequency with the cells in flow. We describe a scheme to fabricate ordered nanopillar forests on the sidewalls of these micro posts and functionalize them with SELEX nucleic acid aptamers. Our microfluidic platform, designed for 90% contact probability, facilitates technologies for highly selective and specific capture of circulating tumor cells.

Original language	English (US)
Title of host publication	2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013
Pages	370-373
Number of pages	4
DOIs	https://doi.org/10.1109/NANO.2013.6720968
State	Published - 2013
Event	2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013 - Beijing, China Duration: Aug 5 2013 → Aug 8 2013

Publication series

Name	Proceedings of the IEEE Conference on Nanotechnology
ISSN (Print)	1944-9399
ISSN (Electronic)	1944-9380

Other

Other	2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013
Country/Territory	China
City	Beijing
Period	8/5/13 → 8/8/13

All Science Journal Classification (ASJC) codes

Bioengineering
Electrical and Electronic Engineering
Materials Chemistry
Condensed Matter Physics

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10.1109/NANO.2013.6720968

Cite this

Swaminathan, V. V., Gannavaram, S., Li, S., Hu, H., Yeom, J., Wang, Y., & Zhu, L. (2013). Microfluidic platform with hierarchical micro/nanostructures and SELEX nucleic acid aptamer coating for isolation of circulating tumor cells. In 2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013 (pp. 370-373). Article 6720968 (Proceedings of the IEEE Conference on Nanotechnology). https://doi.org/10.1109/NANO.2013.6720968

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title = "Microfluidic platform with hierarchical micro/nanostructures and SELEX nucleic acid aptamer coating for isolation of circulating tumor cells",

abstract = "Microfluidic platforms provide elegant schemes for isolation of rare cells from the blood. Hierarchical 3-dimensional architectures with silicon nanopillar forests draw advantage of unique surface interactions with target cells to aid capture and adhesion. Microchannels with numerically optimized designs of micro post arrays maximize contact frequency with the cells in flow. We describe a scheme to fabricate ordered nanopillar forests on the sidewalls of these micro posts and functionalize them with SELEX nucleic acid aptamers. Our microfluidic platform, designed for 90% contact probability, facilitates technologies for highly selective and specific capture of circulating tumor cells.",

author = "Swaminathan, {Vikhram V.} and Spandana Gannavaram and Shihui Li and Huan Hu and Junghoon Yeom and Yong Wang and Likun Zhu",

year = "2013",

doi = "10.1109/NANO.2013.6720968",

language = "English (US)",

isbn = "9781479906758",

series = "Proceedings of the IEEE Conference on Nanotechnology",

pages = "370--373",

booktitle = "2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013",

note = "2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013 ; Conference date: 05-08-2013 Through 08-08-2013",

}

Swaminathan, VV, Gannavaram, S, Li, S, Hu, H, Yeom, J, Wang, Y & Zhu, L 2013, Microfluidic platform with hierarchical micro/nanostructures and SELEX nucleic acid aptamer coating for isolation of circulating tumor cells. in 2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013., 6720968, Proceedings of the IEEE Conference on Nanotechnology, pp. 370-373, 2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013, Beijing, China, 8/5/13. https://doi.org/10.1109/NANO.2013.6720968

Microfluidic platform with hierarchical micro/nanostructures and SELEX nucleic acid aptamer coating for isolation of circulating tumor cells. / Swaminathan, Vikhram V.; Gannavaram, Spandana; Li, Shihui et al.
2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013. 2013. p. 370-373 6720968 (Proceedings of the IEEE Conference on Nanotechnology).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Swaminathan, Vikhram V.

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AU - Hu, Huan

AU - Yeom, Junghoon

AU - Wang, Yong

AU - Zhu, Likun

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AB - Microfluidic platforms provide elegant schemes for isolation of rare cells from the blood. Hierarchical 3-dimensional architectures with silicon nanopillar forests draw advantage of unique surface interactions with target cells to aid capture and adhesion. Microchannels with numerically optimized designs of micro post arrays maximize contact frequency with the cells in flow. We describe a scheme to fabricate ordered nanopillar forests on the sidewalls of these micro posts and functionalize them with SELEX nucleic acid aptamers. Our microfluidic platform, designed for 90% contact probability, facilitates technologies for highly selective and specific capture of circulating tumor cells.

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M3 - Conference contribution

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BT - 2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013

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Swaminathan VV, Gannavaram S, Li S, Hu H, Yeom J, Wang Y et al. Microfluidic platform with hierarchical micro/nanostructures and SELEX nucleic acid aptamer coating for isolation of circulating tumor cells. In 2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013. 2013. p. 370-373. 6720968. (Proceedings of the IEEE Conference on Nanotechnology). doi: 10.1109/NANO.2013.6720968

Microfluidic platform with hierarchical micro/nanostructures and SELEX nucleic acid aptamer coating for isolation of circulating tumor cells

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