Microfluidic-SERS devices for one shot limit-of-detection

Donghyuk Kim; Antonio R. Campos; Ashish Datt; Zhe Gao; Matthew Rycenga; Nathan D. Burrows; Nathan G. Greeneltch; Nathan G. Greeneltch; Chad A. Mirkin; Catherine J. Murphy; Richard P. Van Duyne; Christy L. Haynes

doi:10.1039/c4an00357h

Microfluidic-SERS devices for one shot limit-of-detection

Donghyuk Kim, Antonio R. Campos, Ashish Datt, Zhe Gao, Matthew Rycenga, Nathan D. Burrows, Nathan G. Greeneltch, Nathan G. Greeneltch, Chad A. Mirkin, Catherine J. Murphy, Richard P. Van Duyne, Christy L. Haynes

Chemistry

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Microfluidic sensing platforms facilitate parallel, low sample volume detection using various optical signal transduction mechanisms. Herein, we introduce a simple mixing microfluidic device, enabling serial dilution of introduced analyte solution that terminates in five discrete sensing elements. We demonstrate the utility of this device with on-chip fluorescence and surface-enhanced Raman scattering (SERS) detection of analytes, and we demonstrate device use both when combined with a traditional inflexible SERS substrate and with SERS-active nanoparticles that are directly incorporated into microfluidic channels to create a flexible SERS platform. The results indicate, with varying sensitivities, that either flexible or inflexible devices can be easily used to create a calibration curve and perform a limit of detection study with a single experiment.

Original language	English (US)
Pages (from-to)	3227-3234
Number of pages	8
Journal	Analyst
Volume	139
Issue number	13
DOIs	https://doi.org/10.1039/c4an00357h
State	Published - Jun 3 2014

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Environmental Chemistry
Spectroscopy
Electrochemistry

Access to Document

10.1039/c4an00357h

Cite this

@article{27e1398c7f2242b0854814b666ebf6da,

title = "Microfluidic-SERS devices for one shot limit-of-detection",

abstract = "Microfluidic sensing platforms facilitate parallel, low sample volume detection using various optical signal transduction mechanisms. Herein, we introduce a simple mixing microfluidic device, enabling serial dilution of introduced analyte solution that terminates in five discrete sensing elements. We demonstrate the utility of this device with on-chip fluorescence and surface-enhanced Raman scattering (SERS) detection of analytes, and we demonstrate device use both when combined with a traditional inflexible SERS substrate and with SERS-active nanoparticles that are directly incorporated into microfluidic channels to create a flexible SERS platform. The results indicate, with varying sensitivities, that either flexible or inflexible devices can be easily used to create a calibration curve and perform a limit of detection study with a single experiment.",

author = "Donghyuk Kim and Campos, {Antonio R.} and Ashish Datt and Zhe Gao and Matthew Rycenga and Burrows, {Nathan D.} and Greeneltch, {Nathan G.} and Greeneltch, {Nathan G.} and Mirkin, {Chad A.} and Murphy, {Catherine J.} and {Van Duyne}, {Richard P.} and Haynes, {Christy L.}",

year = "2014",

month = jun,

day = "3",

doi = "10.1039/c4an00357h",

language = "English (US)",

volume = "139",

pages = "3227--3234",

journal = "Analyst",

issn = "0003-2654",

publisher = "Royal Society of Chemistry",

number = "13",

}

TY - JOUR

T1 - Microfluidic-SERS devices for one shot limit-of-detection

AU - Kim, Donghyuk

AU - Campos, Antonio R.

AU - Datt, Ashish

AU - Gao, Zhe

AU - Rycenga, Matthew

AU - Burrows, Nathan D.

AU - Greeneltch, Nathan G.

AU - Mirkin, Chad A.

AU - Murphy, Catherine J.

AU - Van Duyne, Richard P.

AU - Haynes, Christy L.

PY - 2014/6/3

Y1 - 2014/6/3

N2 - Microfluidic sensing platforms facilitate parallel, low sample volume detection using various optical signal transduction mechanisms. Herein, we introduce a simple mixing microfluidic device, enabling serial dilution of introduced analyte solution that terminates in five discrete sensing elements. We demonstrate the utility of this device with on-chip fluorescence and surface-enhanced Raman scattering (SERS) detection of analytes, and we demonstrate device use both when combined with a traditional inflexible SERS substrate and with SERS-active nanoparticles that are directly incorporated into microfluidic channels to create a flexible SERS platform. The results indicate, with varying sensitivities, that either flexible or inflexible devices can be easily used to create a calibration curve and perform a limit of detection study with a single experiment.

AB - Microfluidic sensing platforms facilitate parallel, low sample volume detection using various optical signal transduction mechanisms. Herein, we introduce a simple mixing microfluidic device, enabling serial dilution of introduced analyte solution that terminates in five discrete sensing elements. We demonstrate the utility of this device with on-chip fluorescence and surface-enhanced Raman scattering (SERS) detection of analytes, and we demonstrate device use both when combined with a traditional inflexible SERS substrate and with SERS-active nanoparticles that are directly incorporated into microfluidic channels to create a flexible SERS platform. The results indicate, with varying sensitivities, that either flexible or inflexible devices can be easily used to create a calibration curve and perform a limit of detection study with a single experiment.

UR - http://www.scopus.com/inward/record.url?scp=84901926493&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901926493&partnerID=8YFLogxK

U2 - 10.1039/c4an00357h

DO - 10.1039/c4an00357h

M3 - Article

C2 - 24756225

AN - SCOPUS:84901926493

SN - 0003-2654

VL - 139

SP - 3227

EP - 3234

JO - Analyst

JF - Analyst

IS - 13

ER -

Microfluidic-SERS devices for one shot limit-of-detection

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this