Microfluidic-SERS devices for one shot limit-of-detection

Donghyuk Kim, Antonio R. Campos, Ashish Datt, Zhe Gao, Matthew Rycenga, Nathan D. Burrows, Nathan G. Greeneltch, Nathan G. Greeneltch, Chad A. Mirkin, Catherine J. Murphy, Richard P. Van Duyne, Christy L. Haynes

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Microfluidic sensing platforms facilitate parallel, low sample volume detection using various optical signal transduction mechanisms. Herein, we introduce a simple mixing microfluidic device, enabling serial dilution of introduced analyte solution that terminates in five discrete sensing elements. We demonstrate the utility of this device with on-chip fluorescence and surface-enhanced Raman scattering (SERS) detection of analytes, and we demonstrate device use both when combined with a traditional inflexible SERS substrate and with SERS-active nanoparticles that are directly incorporated into microfluidic channels to create a flexible SERS platform. The results indicate, with varying sensitivities, that either flexible or inflexible devices can be easily used to create a calibration curve and perform a limit of detection study with a single experiment.

Original languageEnglish (US)
Pages (from-to)3227-3234
Number of pages8
Issue number13
StatePublished - Jun 3 2014

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry


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