Micromechanics of tumor cell adhesion and migration under dynamic flow conditions

Cheng Dong; Maggie Slattery; Shile Liang

Micromechanics of tumor cell adhesion and migration under dynamic flow conditions

Cheng Dong, Maggie Slattery, Shile Liang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Attachment of tumor cells to endothelial cells is critical for migration of tumor cells out of the vascular system to establish metastases. We have studied human melanoma cell (C8161) adhesion and migration in response to stimulation by soluble collagen IV (CIV) using a modified Boyden chamber. In this modified chamber, shear flow can be introduced over the cell-substrate interface affecting tumor cell chemotactic migration through a microporous filter. Our results suggest that transmigration of C8161 cells under flaw conditions can be influenced by PMNs, mediated by Mac-1/ICAM-1 adhesive interactions and enhanced by altered cytokine production.

Original language	English (US)
Title of host publication	Proceedings of the Second IASTED International Conference on Biomechanics
Editors	M.H. Hamza
Pages	150-155
Number of pages	6
State	Published - 2004
Event	Proceedings of the Second IASTED International Conference on Biomechanics - Honolulu, HI, United States Duration: Aug 23 2004 → Aug 25 2004

Publication series

Name	Proceedings of the Second IASTED International Conference on Biomechanics

Other

Other	Proceedings of the Second IASTED International Conference on Biomechanics
Country/Territory	United States
City	Honolulu, HI
Period	8/23/04 → 8/25/04

All Science Journal Classification (ASJC) codes

General Engineering

Cite this

@inproceedings{2f97ae8d601146a1874ef67ee35e6e64,

title = "Micromechanics of tumor cell adhesion and migration under dynamic flow conditions",

abstract = "Attachment of tumor cells to endothelial cells is critical for migration of tumor cells out of the vascular system to establish metastases. We have studied human melanoma cell (C8161) adhesion and migration in response to stimulation by soluble collagen IV (CIV) using a modified Boyden chamber. In this modified chamber, shear flow can be introduced over the cell-substrate interface affecting tumor cell chemotactic migration through a microporous filter. Our results suggest that transmigration of C8161 cells under flaw conditions can be influenced by PMNs, mediated by Mac-1/ICAM-1 adhesive interactions and enhanced by altered cytokine production.",

author = "Cheng Dong and Maggie Slattery and Shile Liang",

year = "2004",

language = "English (US)",

isbn = "0889864489",

series = "Proceedings of the Second IASTED International Conference on Biomechanics",

pages = "150--155",

editor = "M.H. Hamza",

booktitle = "Proceedings of the Second IASTED International Conference on Biomechanics",

note = "Proceedings of the Second IASTED International Conference on Biomechanics ; Conference date: 23-08-2004 Through 25-08-2004",

}

Dong, C, Slattery, M & Liang, S 2004, Micromechanics of tumor cell adhesion and migration under dynamic flow conditions. in MH Hamza (ed.), Proceedings of the Second IASTED International Conference on Biomechanics., 463-053, Proceedings of the Second IASTED International Conference on Biomechanics, pp. 150-155, Proceedings of the Second IASTED International Conference on Biomechanics, Honolulu, HI, United States, 8/23/04.

Micromechanics of tumor cell adhesion and migration under dynamic flow conditions. / Dong, Cheng; Slattery, Maggie; Liang, Shile.
Proceedings of the Second IASTED International Conference on Biomechanics. ed. / M.H. Hamza. 2004. p. 150-155 463-053 (Proceedings of the Second IASTED International Conference on Biomechanics).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Micromechanics of tumor cell adhesion and migration under dynamic flow conditions

AU - Dong, Cheng

AU - Slattery, Maggie

AU - Liang, Shile

PY - 2004

Y1 - 2004

N2 - Attachment of tumor cells to endothelial cells is critical for migration of tumor cells out of the vascular system to establish metastases. We have studied human melanoma cell (C8161) adhesion and migration in response to stimulation by soluble collagen IV (CIV) using a modified Boyden chamber. In this modified chamber, shear flow can be introduced over the cell-substrate interface affecting tumor cell chemotactic migration through a microporous filter. Our results suggest that transmigration of C8161 cells under flaw conditions can be influenced by PMNs, mediated by Mac-1/ICAM-1 adhesive interactions and enhanced by altered cytokine production.

AB - Attachment of tumor cells to endothelial cells is critical for migration of tumor cells out of the vascular system to establish metastases. We have studied human melanoma cell (C8161) adhesion and migration in response to stimulation by soluble collagen IV (CIV) using a modified Boyden chamber. In this modified chamber, shear flow can be introduced over the cell-substrate interface affecting tumor cell chemotactic migration through a microporous filter. Our results suggest that transmigration of C8161 cells under flaw conditions can be influenced by PMNs, mediated by Mac-1/ICAM-1 adhesive interactions and enhanced by altered cytokine production.

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UR - http://www.scopus.com/inward/citedby.url?scp=11144307394&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:11144307394

SN - 0889864489

SN - 9780889864481

T3 - Proceedings of the Second IASTED International Conference on Biomechanics

SP - 150

EP - 155

BT - Proceedings of the Second IASTED International Conference on Biomechanics

A2 - Hamza, M.H.

T2 - Proceedings of the Second IASTED International Conference on Biomechanics

Y2 - 23 August 2004 through 25 August 2004

ER -

Micromechanics of tumor cell adhesion and migration under dynamic flow conditions

Abstract

Publication series

Other

All Science Journal Classification (ASJC) codes

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