Micromotors Powered by Enzyme Catalysis

Krishna K. Dey; Xi Zhao; Benjamin M. Tansi; Wilfredo J. Méndez-Ortiz; Ubaldo M. Córdova-Figueroa; Ramin Golestanian; Ayusman Sen

doi:10.1021/acs.nanolett.5b03935

Micromotors Powered by Enzyme Catalysis

Krishna K. Dey, Xi Zhao, Benjamin M. Tansi, Wilfredo J. Méndez-Ortiz, Ubaldo M. Córdova-Figueroa, Ramin Golestanian, Ayusman Sen

Research output: Contribution to journal › Article › peer-review

212 Scopus citations

Abstract

Active biocompatible systems are of great current interest for their possible applications in drug or antidote delivery at specific locations. Herein, we report the synthesis and study of self-propelled microparticles powered by enzymatic reactions and their directed movement in substrate concentration gradient. Polystyrene microparticles were functionalized with the enzymes urease and catalase using a biotin-streptavidin linkage procedure. The motion of the enzyme-coated particles was studied in the presence of the respective substrates, using optical microscopy and dynamic light scattering analysis. The diffusion of the particles was found to increase in a substrate concentration dependent manner. The directed chemotactic movement of these enzyme-powered motors up the substrate gradient was studied using three-inlet microfluidic channel architecture.

Original language	English (US)
Pages (from-to)	8311-8315
Number of pages	5
Journal	Nano letters
Volume	15
Issue number	12
DOIs	https://doi.org/10.1021/acs.nanolett.5b03935
State	Published - Dec 9 2015

All Science Journal Classification (ASJC) codes

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/acs.nanolett.5b03935

Cite this

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abstract = "Active biocompatible systems are of great current interest for their possible applications in drug or antidote delivery at specific locations. Herein, we report the synthesis and study of self-propelled microparticles powered by enzymatic reactions and their directed movement in substrate concentration gradient. Polystyrene microparticles were functionalized with the enzymes urease and catalase using a biotin-streptavidin linkage procedure. The motion of the enzyme-coated particles was studied in the presence of the respective substrates, using optical microscopy and dynamic light scattering analysis. The diffusion of the particles was found to increase in a substrate concentration dependent manner. The directed chemotactic movement of these enzyme-powered motors up the substrate gradient was studied using three-inlet microfluidic channel architecture.",

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T1 - Micromotors Powered by Enzyme Catalysis

AU - Dey, Krishna K.

AU - Zhao, Xi

AU - Tansi, Benjamin M.

AU - Méndez-Ortiz, Wilfredo J.

AU - Córdova-Figueroa, Ubaldo M.

AU - Golestanian, Ramin

AU - Sen, Ayusman

PY - 2015/12/9

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AB - Active biocompatible systems are of great current interest for their possible applications in drug or antidote delivery at specific locations. Herein, we report the synthesis and study of self-propelled microparticles powered by enzymatic reactions and their directed movement in substrate concentration gradient. Polystyrene microparticles were functionalized with the enzymes urease and catalase using a biotin-streptavidin linkage procedure. The motion of the enzyme-coated particles was studied in the presence of the respective substrates, using optical microscopy and dynamic light scattering analysis. The diffusion of the particles was found to increase in a substrate concentration dependent manner. The directed chemotactic movement of these enzyme-powered motors up the substrate gradient was studied using three-inlet microfluidic channel architecture.

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Micromotors Powered by Enzyme Catalysis

Abstract

All Science Journal Classification (ASJC) codes

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