TY - JOUR
T1 - Micronutrients, inflammation and congestive heart failure among the elderly
T2 - Nutritional perspectives on primary prevention and clinical treatment
AU - Liu, Longjian
AU - Yin, Xiaoyan
AU - Ikeda, Katsumi
AU - Sullivan, Dennis H.
AU - Eisen, Howard J.
PY - 2007/11
Y1 - 2007/11
N2 - 1. The aim of the present study was to examine the associations between micronutrients, inflammation and the prevalence of congestive heart failure (CHF) in the elderly aged 65 years, using the US National Health and Nutrition Examination Surveys. 2. After adjusting for age, gender, race/ethnicity and other covariates, subjects with decreased folate and vitamin B 12 intake and with elevated serum levels of inflammatory biomarkers (C-reactive protein and total homocysteine) had significantly higher risk of CHF than their counterparts. 3. Elderly women had a significantly higher prevalence of hypovitaminosis D (serum 25-Hydroxyvitamin(OH)D < 20 ng/mL) than men (37 vs 23%, respectively; P < 0.01). Elderly African Americans had the lowest mean levels of serum 25(OH)D (20.9 ng/mL) compared with Mexican Americans (24.1 ng/mL) and Caucasians (28.2 ng/mL). 4. Subjects with decreased serum 25(OH)D levels had a significantly higher prevalence of CHF than those who had higher serum 25(OH)D, for both men and women. Multivariate logistic regression analyses indicated that a decrease of 10 ng/mL in the serum 25(OH)D level was associated with an increased relative risk (95% confidence interval) of 1.22 (1.08-1.36) for CHF. 5. Subjects with a micronutrient insufficient status and with coexisting metabolic syndrome had an even higher risk of CHF.
AB - 1. The aim of the present study was to examine the associations between micronutrients, inflammation and the prevalence of congestive heart failure (CHF) in the elderly aged 65 years, using the US National Health and Nutrition Examination Surveys. 2. After adjusting for age, gender, race/ethnicity and other covariates, subjects with decreased folate and vitamin B 12 intake and with elevated serum levels of inflammatory biomarkers (C-reactive protein and total homocysteine) had significantly higher risk of CHF than their counterparts. 3. Elderly women had a significantly higher prevalence of hypovitaminosis D (serum 25-Hydroxyvitamin(OH)D < 20 ng/mL) than men (37 vs 23%, respectively; P < 0.01). Elderly African Americans had the lowest mean levels of serum 25(OH)D (20.9 ng/mL) compared with Mexican Americans (24.1 ng/mL) and Caucasians (28.2 ng/mL). 4. Subjects with decreased serum 25(OH)D levels had a significantly higher prevalence of CHF than those who had higher serum 25(OH)D, for both men and women. Multivariate logistic regression analyses indicated that a decrease of 10 ng/mL in the serum 25(OH)D level was associated with an increased relative risk (95% confidence interval) of 1.22 (1.08-1.36) for CHF. 5. Subjects with a micronutrient insufficient status and with coexisting metabolic syndrome had an even higher risk of CHF.
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U2 - 10.1111/j.1440-1681.2007.04762.x
DO - 10.1111/j.1440-1681.2007.04762.x
M3 - Article
AN - SCOPUS:35748946301
SN - 0305-1870
VL - 34
SP - S14-S16
JO - Clinical and Experimental Pharmacology and Physiology
JF - Clinical and Experimental Pharmacology and Physiology
IS - SUPPL. 1
ER -