TY - JOUR
T1 - MicroRNA-340 as a modulator of RAS-RAF-MAPK signaling in melanoma
AU - Poenitzsch Strong, Ashley M.
AU - Setaluri, Vijayasaradhi
AU - Spiegelman, Vladimir
N1 - Funding Information:
We would like to thank Edwarda Desouza and Emily Adochio for their technical assistance. We would also like to thank Drs. Meenhard Herlyn, Yiqun Shellman, Paul Robbins and Anja Katrin Bosserhoff for their generous gifts of reagents. This research is supported by NIEHS training Grant ES007015 (to A.M.P.) and NIAMS grant AR063361 (to V.S.S.).
Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2014/12/15
Y1 - 2014/12/15
N2 - microRNA (miRNA)-dependent regulation of gene expression is increasingly linked to development and progression of melanoma. In this study we evaluated the functions of miR-340 in human melanoma cells. Here, we show that miR-340 inhibits the tumorigenic phenotype of melanoma cells. We also found that miR-340 regulates RAS-RAF-Mitogen Activated Protein Kinase (MAPK) signaling by modulating the expression of multiple components of this pathway. Given the importance of MAPK signaling in melanoma, these results provide further insight into the pathogenesis of melanoma.
AB - microRNA (miRNA)-dependent regulation of gene expression is increasingly linked to development and progression of melanoma. In this study we evaluated the functions of miR-340 in human melanoma cells. Here, we show that miR-340 inhibits the tumorigenic phenotype of melanoma cells. We also found that miR-340 regulates RAS-RAF-Mitogen Activated Protein Kinase (MAPK) signaling by modulating the expression of multiple components of this pathway. Given the importance of MAPK signaling in melanoma, these results provide further insight into the pathogenesis of melanoma.
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U2 - 10.1016/j.abb.2014.07.012
DO - 10.1016/j.abb.2014.07.012
M3 - Article
C2 - 25043973
AN - SCOPUS:84908400260
SN - 0003-9861
VL - 563
SP - 118
EP - 124
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
ER -