TY - JOUR
T1 - MicroRNA expression and function in cardiac ischemic injury
AU - Yu, Shiyong
AU - Li, Guohong
N1 - Funding Information:
Acknowledgments The work was supported by the National Institutes of Health Grant HL087990 (Dr. Li) and by the American Heart Association grant 0530166N (Dr. Li).
PY - 2010/6
Y1 - 2010/6
N2 - Ischemic heart disease (IHD) or myocardial ischemia is one of the leading causes of mortality all over the world. There is a definite need for new approaches to improve therapies and diagnostics. The pathological process leading to IHD is associated with an altered expression of genes that are important for cardiac functions. Micro- RNAs (miRNAs) have emerged as one of the central players regulating gene expression via degradation or translational inhibition of their target genes. Increasing evidence indicates that miRNAs may serve as potential diagnostic biomarkers and innovative therapeutic targets in several human diseases including cardiovascular disease. Here, we review the latest advances in the identification and validation of myocardial ischemia-related miRNAs and their target genes and discuss the roles of specific miRNAs in regulating ischemia-related cardiac injury, including apoptosis, fibrosis, arrhythmia, and angiogenesis.
AB - Ischemic heart disease (IHD) or myocardial ischemia is one of the leading causes of mortality all over the world. There is a definite need for new approaches to improve therapies and diagnostics. The pathological process leading to IHD is associated with an altered expression of genes that are important for cardiac functions. Micro- RNAs (miRNAs) have emerged as one of the central players regulating gene expression via degradation or translational inhibition of their target genes. Increasing evidence indicates that miRNAs may serve as potential diagnostic biomarkers and innovative therapeutic targets in several human diseases including cardiovascular disease. Here, we review the latest advances in the identification and validation of myocardial ischemia-related miRNAs and their target genes and discuss the roles of specific miRNAs in regulating ischemia-related cardiac injury, including apoptosis, fibrosis, arrhythmia, and angiogenesis.
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U2 - 10.1007/s12265-010-9168-8
DO - 10.1007/s12265-010-9168-8
M3 - Review article
C2 - 20535240
AN - SCOPUS:77955658952
SN - 1937-5387
VL - 3
SP - 241
EP - 245
JO - Journal of cardiovascular translational research
JF - Journal of cardiovascular translational research
IS - 3
ER -