Abstract
MicroRNAs are key regulators of the immune response, but their role in CD8 T cell differentiation in vivo is not known. We show that miR-155 is important in both effector and memory antiviral CD8 T cell responses. Without miR-155, there was a weaker effector response and a skewing toward memory precursor cells. At the memory stage, miR-155-deficient CD8 T cells preferentially differentiated into central memory cells and were capable of mounting a potent secondary response.
Original language | English (US) |
---|---|
Pages (from-to) | 2348-2351 |
Number of pages | 4 |
Journal | Journal of virology |
Volume | 87 |
Issue number | 4 |
DOIs | |
State | Published - Feb 2013 |
All Science Journal Classification (ASJC) codes
- Microbiology
- Immunology
- Insect Science
- Virology