TY - JOUR
T1 - Microtubule dynamics in healthy and injured neurons
AU - Rolls, Melissa M.
AU - Thyagarajan, Pankajam
AU - Feng, Chengye
N1 - Funding Information:
We are grateful to the Bloomington Drosophila Stock Center (NIH P40OD018537) and Dr. Vladimir Gelfand for the Drosophila lines used in Figure 3. Past and present members of the Rolls lab have provided valuable perspectives. Funding for microtubule work in the Rolls lab was provided by the National Institutes of Health, R01 GM085115.
Funding Information:
We are grateful to the Bloomington Drosophila Stock Center (NIH P40OD018537) and Dr. Vladimir Gelfand for the Drosophila lines used in Figure 3 . Past and present members of the Rolls lab have provided valuable perspectives. Funding for microtubule work in the Rolls lab was provided by the National Institutes of Health, R01 GM085115.
Publisher Copyright:
© 2020 Wiley Periodicals, Inc.
PY - 2021/4
Y1 - 2021/4
N2 - Most neurons must last a lifetime and their microtubule cytoskeleton is an important contributor to their longevity. Neurons have some of the most stable microtubules of all cells, but the tip of every microtubule remains dynamic and, although requiring constant GTP consumption, microtubules are always being rebuilt. While some ongoing level of rebuilding always occurs, overall microtubule stability can be modulated in response to injury and stress as well as the normal developmental process of pruning. Specific microtubule severing proteins act in different contexts to increase microtubule dynamicity and promote degeneration and pruning. After axon injury, complex changes in dynamics occur and these are important for both neuroprotection induced by injury and subsequent outgrowth of a new axon. Understanding how microtubule dynamics is modulated in different scenarios, as well as the impact of the changes in stability, is an important avenue to explore for development of strategies to promote neuroprotection and regeneration.
AB - Most neurons must last a lifetime and their microtubule cytoskeleton is an important contributor to their longevity. Neurons have some of the most stable microtubules of all cells, but the tip of every microtubule remains dynamic and, although requiring constant GTP consumption, microtubules are always being rebuilt. While some ongoing level of rebuilding always occurs, overall microtubule stability can be modulated in response to injury and stress as well as the normal developmental process of pruning. Specific microtubule severing proteins act in different contexts to increase microtubule dynamicity and promote degeneration and pruning. After axon injury, complex changes in dynamics occur and these are important for both neuroprotection induced by injury and subsequent outgrowth of a new axon. Understanding how microtubule dynamics is modulated in different scenarios, as well as the impact of the changes in stability, is an important avenue to explore for development of strategies to promote neuroprotection and regeneration.
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U2 - 10.1002/dneu.22746
DO - 10.1002/dneu.22746
M3 - Review article
C2 - 32291942
AN - SCOPUS:85084079437
SN - 1932-8451
VL - 81
SP - 321
EP - 332
JO - Developmental Neurobiology
JF - Developmental Neurobiology
IS - 3
ER -