Microwave-assisted suzuki cross-coupling reaction, a key step in the synthesis of polycyclic aromatic hydrocarbons and their metabolites

Arun K. Sharma; Krishnegowda Gowdahalli; Jacek Krzeminski; Shantu Amin

doi:10.1021/jo701665j

Microwave-assisted suzuki cross-coupling reaction, a key step in the synthesis of polycyclic aromatic hydrocarbons and their metabolites

Arun K. Sharma, Krishnegowda Gowdahalli, Jacek Krzeminski, Shantu Amin

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

(Chemical Equation Presented) A highly efficient and general method for Suzuki cross-coupling reaction en route to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and their metabolites has been developed. Microwave irradiation of aryl bromides 1 and boronic acids (2 and 3) using polyurea microencapsulated palladium catalyst (Pd EnCat 30) gave the coupling adducts 4 and 5 in excellent yields in just 20 min compared to ∼24 h under thermal conditions, corresponding to a ∼72-fold increase in reaction rate.

Original language	English (US)
Pages (from-to)	8987-8989
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	72
Issue number	23
DOIs	https://doi.org/10.1021/jo701665j
State	Published - Nov 9 2007

All Science Journal Classification (ASJC) codes

Organic Chemistry

Access to Document

10.1021/jo701665j

Cite this

@article{be5a31e0a24c4c7bace1bbad0fb1a8ac,

title = "Microwave-assisted suzuki cross-coupling reaction, a key step in the synthesis of polycyclic aromatic hydrocarbons and their metabolites",

abstract = "(Chemical Equation Presented) A highly efficient and general method for Suzuki cross-coupling reaction en route to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and their metabolites has been developed. Microwave irradiation of aryl bromides 1 and boronic acids (2 and 3) using polyurea microencapsulated palladium catalyst (Pd EnCat 30) gave the coupling adducts 4 and 5 in excellent yields in just 20 min compared to ∼24 h under thermal conditions, corresponding to a ∼72-fold increase in reaction rate.",

author = "Sharma, {Arun K.} and Krishnegowda Gowdahalli and Jacek Krzeminski and Shantu Amin",

year = "2007",

month = nov,

day = "9",

doi = "10.1021/jo701665j",

language = "English (US)",

volume = "72",

pages = "8987--8989",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "23",

}

TY - JOUR

T1 - Microwave-assisted suzuki cross-coupling reaction, a key step in the synthesis of polycyclic aromatic hydrocarbons and their metabolites

AU - Sharma, Arun K.

AU - Gowdahalli, Krishnegowda

AU - Krzeminski, Jacek

AU - Amin, Shantu

PY - 2007/11/9

Y1 - 2007/11/9

N2 - (Chemical Equation Presented) A highly efficient and general method for Suzuki cross-coupling reaction en route to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and their metabolites has been developed. Microwave irradiation of aryl bromides 1 and boronic acids (2 and 3) using polyurea microencapsulated palladium catalyst (Pd EnCat 30) gave the coupling adducts 4 and 5 in excellent yields in just 20 min compared to ∼24 h under thermal conditions, corresponding to a ∼72-fold increase in reaction rate.

AB - (Chemical Equation Presented) A highly efficient and general method for Suzuki cross-coupling reaction en route to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and their metabolites has been developed. Microwave irradiation of aryl bromides 1 and boronic acids (2 and 3) using polyurea microencapsulated palladium catalyst (Pd EnCat 30) gave the coupling adducts 4 and 5 in excellent yields in just 20 min compared to ∼24 h under thermal conditions, corresponding to a ∼72-fold increase in reaction rate.

UR - http://www.scopus.com/inward/record.url?scp=35948956601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35948956601&partnerID=8YFLogxK

U2 - 10.1021/jo701665j

DO - 10.1021/jo701665j

M3 - Article

C2 - 17939722

AN - SCOPUS:35948956601

SN - 0022-3263

VL - 72

SP - 8987

EP - 8989

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 23

ER -

Microwave-assisted suzuki cross-coupling reaction, a key step in the synthesis of polycyclic aromatic hydrocarbons and their metabolites

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this