Mitochondrial Ca2+ signaling

Trayambak Pathak, Mohamed Trebak

Research output: Contribution to journalReview articlepeer-review

116 Scopus citations


Mitochondrial Ca2+ regulation is crucial for bioenergetics and cellular signaling. The mechanisms controlling mitochondrial calcium homeostasis have been recently unraveled with the discovery of mitochondrial inner membrane proteins that regulate mitochondrial Ca2+ uptake and extrusion. Mitochondrial Ca2+ uptake depends on a large complex of proteins centered around the Ca2+ channel protein, mitochondrial Ca2+ uniporter (MCU) in close interactions with several regulatory subunits (MCUb, EMRE, MICU1, MICU2). Mitochondrial Ca2+ extrusion is mainly mediated by the mitochondrial Na+/Ca2+/Li+ exchanger (NCLX). Here, we review the major players of mitochondrial Ca2+ homeostasis and their physiological functions.

Original languageEnglish (US)
Pages (from-to)112-123
Number of pages12
JournalPharmacology and Therapeutics
StatePublished - Dec 2018

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)


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