TY - JOUR
T1 - Mitochondria–Lysosome Crosstalk
T2 - From Physiology to Neurodegeneration
AU - Deus, Cláudia M.
AU - Yambire, King Faisal
AU - Oliveira, Paulo J.
AU - Raimundo, Nuno
N1 - Funding Information:
The laboratory of N.R. is supported by the European Research Council (ERC; Stg 337327 MitoPexLysoNETWORK), and by the Deutsche Forschungsgemeinschaft ( SFB1190-P02 ). C.D. is supported by a doctoral fellowship from the Fundação para a Ciência e a Tecnologia (FCT) Portugal (SFRH/BD/100341/2014). The laboratory of P.J.O. was supported by the Montepio Foundation under the project 'An Epigenetic Engineering Approach to Reverse the Parkinson Disease Cell State (PD-state)' (CPD0028001; 2015), by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme under project CENTRO-07-ST24-FEDER-002008 and through the COMPETE 2020 Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via the FCT under project(s) PTDC/BIA-MOL/28607/2017, POCI-01-0145-FEDER-028607, PTDC/BTM-SAL/29297/2017, POCI-01-0145-FEDER-02929, PTDC/MED-FAR/29391/2017, POCI-01-0145-FEDER-029391, and UID/NEU/04539/2019.
Funding Information:
The laboratory of N.R. is supported by the European Research Council (ERC; Stg 337327 MitoPexLysoNETWORK), and by the Deutsche Forschungsgemeinschaft (SFB1190-P02). C.D. is supported by a doctoral fellowship from the Funda??o para a Ci?ncia e a Tecnologia (FCT) Portugal (SFRH/BD/100341/2014). The laboratory of P.J.O. was supported by the Montepio Foundation under the project 'An Epigenetic Engineering Approach to Reverse the Parkinson Disease Cell State (PD-state)' (CPD0028001; 2015), by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme under project CENTRO-07-ST24-FEDER-002008 and through the COMPETE 2020 Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via the FCT under project(s) PTDC/BIA-MOL/28607/2017, POCI-01-0145-FEDER-028607, PTDC/BTM-SAL/29297/2017, POCI-01-0145-FEDER-02929, PTDC/MED-FAR/29391/2017, POCI-01-0145-FEDER-029391, and UID/NEU/04539/2019.
Publisher Copyright:
© 2019 The Author(s)
PY - 2020/1
Y1 - 2020/1
N2 - Cellular function requires coordination between different organelles and metabolic cues. Mitochondria and lysosomes are essential for cellular metabolism as major contributors of chemical energy and building blocks. It is therefore pivotal for cellular function to coordinate the metabolic roles of mitochondria and lysosomes. However, these organelles do more than metabolism, given their function as fundamental signaling platforms in the cell that regulate many key processes such as autophagy, proliferation, and cell death. Mechanisms of crosstalk between mitochondria and lysosomes are discussed, both under physiological conditions and in diseases that affect these organelles.
AB - Cellular function requires coordination between different organelles and metabolic cues. Mitochondria and lysosomes are essential for cellular metabolism as major contributors of chemical energy and building blocks. It is therefore pivotal for cellular function to coordinate the metabolic roles of mitochondria and lysosomes. However, these organelles do more than metabolism, given their function as fundamental signaling platforms in the cell that regulate many key processes such as autophagy, proliferation, and cell death. Mechanisms of crosstalk between mitochondria and lysosomes are discussed, both under physiological conditions and in diseases that affect these organelles.
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U2 - 10.1016/j.molmed.2019.10.009
DO - 10.1016/j.molmed.2019.10.009
M3 - Review article
C2 - 31791731
AN - SCOPUS:85075815656
SN - 1471-4914
VL - 26
SP - 71
EP - 88
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 1
ER -