Abstract
Abstract. Five lactose‐inhibitable lectins have been isolated from snake venoms. These five share certain biochemical properties but are not identical (Gartner, Stocker & Williams, 1980; Gartner & Ogilvie, 1984). In this study the lectins were tested for their ability to stimulate lymphocytes to undergo DNA synthesis. We found that three of the lectins were comparable in mitogenic activity to the T cell lectin, concanavalin A (Con A). the mitogenic activity was blocked by lactose, a sugar which also blocks the haemagglutination activity of these lectins. Although mitogenic response appeared to be due to T cells, it depended on the presence of accessory cells in the culture. This requirement for macrophages could be replaced by the phorbol ester tumour promoter, 12‐o‐tetradecanoylphorbol‐13‐acetate (TPA).
Original language | English (US) |
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Pages (from-to) | 557-566 |
Number of pages | 10 |
Journal | Cell Proliferation |
Volume | 19 |
Issue number | 5 |
DOIs | |
State | Published - Sep 1986 |
All Science Journal Classification (ASJC) codes
- Cell Biology