Model of unequal chromosomal crossing over in DNA sequences

Nikolay Dokholyan; Sergey V. Buldyrev; Shlomo Havlin; H. Eugene Stanley

doi:10.1016/S0378-4371(97)00520-7

Model of unequal chromosomal crossing over in DNA sequences

Nikolay Dokholyan, Sergey V. Buldyrev, Shlomo Havlin, H. Eugene Stanley

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13 Scopus citations

Abstract

It is known that some dimeric tandem repeats (DTR) are very abundant in noncoding DNA. We find that certain DTR length distribution functions in noncoding DNA can be fit by a power law function. We analyze a simplified model of unequal chromosomal crossing over and find that it produces a stable power law length distribution function, with the exponent μ = 2. Although the exponent predicted by this model differs from those observed in nature, we argue that the biophysical process underlying this model provides the major contribution to the DTR length distribution function.

Original language	English (US)
Pages (from-to)	594-599
Number of pages	6
Journal	Physica A: Statistical Mechanics and its Applications
Volume	249
Issue number	1-4
DOIs	https://doi.org/10.1016/S0378-4371(97)00520-7
State	Published - Jan 2 1998

All Science Journal Classification (ASJC) codes

Statistics and Probability
Condensed Matter Physics

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title = "Model of unequal chromosomal crossing over in DNA sequences",

abstract = "It is known that some dimeric tandem repeats (DTR) are very abundant in noncoding DNA. We find that certain DTR length distribution functions in noncoding DNA can be fit by a power law function. We analyze a simplified model of unequal chromosomal crossing over and find that it produces a stable power law length distribution function, with the exponent μ = 2. Although the exponent predicted by this model differs from those observed in nature, we argue that the biophysical process underlying this model provides the major contribution to the DTR length distribution function.",

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T1 - Model of unequal chromosomal crossing over in DNA sequences

AU - Dokholyan, Nikolay

AU - Buldyrev, Sergey V.

AU - Havlin, Shlomo

AU - Stanley, H. Eugene

N1 - Funding Information: This work is supported by NIH-HGP.

PY - 1998/1/2

Y1 - 1998/1/2

N2 - It is known that some dimeric tandem repeats (DTR) are very abundant in noncoding DNA. We find that certain DTR length distribution functions in noncoding DNA can be fit by a power law function. We analyze a simplified model of unequal chromosomal crossing over and find that it produces a stable power law length distribution function, with the exponent μ = 2. Although the exponent predicted by this model differs from those observed in nature, we argue that the biophysical process underlying this model provides the major contribution to the DTR length distribution function.

AB - It is known that some dimeric tandem repeats (DTR) are very abundant in noncoding DNA. We find that certain DTR length distribution functions in noncoding DNA can be fit by a power law function. We analyze a simplified model of unequal chromosomal crossing over and find that it produces a stable power law length distribution function, with the exponent μ = 2. Although the exponent predicted by this model differs from those observed in nature, we argue that the biophysical process underlying this model provides the major contribution to the DTR length distribution function.

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EP - 599

JO - Physica A: Statistical Mechanics and its Applications

JF - Physica A: Statistical Mechanics and its Applications

IS - 1-4

ER -

Model of unequal chromosomal crossing over in DNA sequences

Abstract

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