Model studies on total synthesis of the chartellines, spirocyclic β-lactam alkaloids from a marine bryozoan

Xichen Lin; Steven M. Weinreb

doi:10.1016/S0040-4039(01)00270-2

Model studies on total synthesis of the chartellines, spirocyclic β-lactam alkaloids from a marine bryozoan

Xichen Lin, Steven M. Weinreb

Chemistry

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

A chartelline alkaloid model system containing a spirocyclic β-lactam moiety and α,β-unsaturated imine has been constructed from isatin using a Staudinger imine-ketene cycloaddition and an addition to an N-activated γ-lactam as key steps.

Original language	English (US)
Pages (from-to)	2631-2633
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Issue number	14
DOIs	https://doi.org/10.1016/S0040-4039(01)00270-2
State	Published - Apr 2 2001

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0040-4039(01)00270-2

Cite this

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title = "Model studies on total synthesis of the chartellines, spirocyclic β-lactam alkaloids from a marine bryozoan",

abstract = "A chartelline alkaloid model system containing a spirocyclic β-lactam moiety and α,β-unsaturated imine has been constructed from isatin using a Staudinger imine-ketene cycloaddition and an addition to an N-activated γ-lactam as key steps.",

author = "Xichen Lin and Weinreb, {Steven M.}",

note = "Funding Information: We are grateful to the National Science Foundation (CHE-97-32038) for financial support of this research. ",

year = "2001",

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AU - Lin, Xichen

AU - Weinreb, Steven M.

N1 - Funding Information: We are grateful to the National Science Foundation (CHE-97-32038) for financial support of this research.

PY - 2001/4/2

Y1 - 2001/4/2

N2 - A chartelline alkaloid model system containing a spirocyclic β-lactam moiety and α,β-unsaturated imine has been constructed from isatin using a Staudinger imine-ketene cycloaddition and an addition to an N-activated γ-lactam as key steps.

AB - A chartelline alkaloid model system containing a spirocyclic β-lactam moiety and α,β-unsaturated imine has been constructed from isatin using a Staudinger imine-ketene cycloaddition and an addition to an N-activated γ-lactam as key steps.

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Model studies on total synthesis of the chartellines, spirocyclic β-lactam alkaloids from a marine bryozoan

Abstract

All Science Journal Classification (ASJC) codes

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