Modeling and simulation of cell nuclear architecture reorganization process

Qing Cheng, Pourya Delafrouz, Jie Liang, Chun Liu, Jie Shen

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


We develop a special phase field/diffusive interface method to model the nuclear architecture reorganization process. In particular, we use a Lagrange multiplier approach in the phase field model to preserve the specific physical and geometrical constraints for the biological events. We develop several efficient and robust linear and weakly nonlinear schemes for this new model. To validate the model and numerical methods, we present ample numerical simulations which in particular reproduce several processes of nuclear architecture reorganization from the experiment literature.

Original languageEnglish (US)
Article number110808
JournalJournal of Computational Physics
StatePublished - Jan 15 2022

All Science Journal Classification (ASJC) codes

  • Numerical Analysis
  • Modeling and Simulation
  • Physics and Astronomy (miscellaneous)
  • General Physics and Astronomy
  • Computer Science Applications
  • Computational Mathematics
  • Applied Mathematics


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