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Abstract

Higher-level functions of complex biological systems are emergent properties that arise from the totality of lower-level elements and interactions. Network models of these systems can provide valuable insight into how the underlying lower-level interactions lead to higher-level emergent properties, and can help predict not-yet-characterized behaviors. This chapter describes the methodologies of network analysis and network-based discrete dynamic modeling and exemplifies them in the context of within-cell information processing networks and their determination of cellular behaviors. In addition to the specific predictions offered by models of individual systems, general insights can be gained by an expanded network representation that integrates the network structure and regulatory logic. This expanded network reveals the connectivity patterns that underlie the system’s functional repertoire, and enables the characterization of their stability and control.

Original languageEnglish (US)
Title of host publicationGraduate Texts in Physics
PublisherSpringer Verlag
Pages213-236
Number of pages24
DOIs
StatePublished - 2022

Publication series

NameGraduate Texts in Physics
VolumePart F7392
ISSN (Print)1868-4513
ISSN (Electronic)1868-4521

All Science Journal Classification (ASJC) codes

  • General Physics and Astronomy

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