Modeling-Enabled Systems Nutritional Immunology

Meghna Verma, Raquel Hontecillas, Vida Abedi, Andrew Leber, Nuria Tubau-Juni, Casandra Philipson, Adria Carbo, Josep Bassaganya-Riera

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


This review highlights the fundamental role of nutrition in the maintenance of health, the immune response, and disease prevention. Emerging global mechanistic insights in the field of nutritional immunology cannot be gained through reductionist methods alone or by analyzing a single nutrient at a time. We propose to investigate nutritional immunology as a massively interacting system of interconnected multistage and multiscale networks that encompass hidden mechanisms by which nutrition, microbiome, metabolism, genetic predisposition, and the immune system interact to delineate health and disease. The review sets an unconventional path to apply complex science methodologies to nutritional immunology research, discovery, and development through “use cases” centered around the impact of nutrition on the gut microbiome and immune responses. Our systems nutritional immunology analyses, which include modeling and informatics methodologies in combination with pre-clinical and clinical studies, have the potential to discover emerging systems-wide properties at the interface of the immune system, nutrition, microbiome, and metabolism.

Original languageEnglish (US)
Article number5
JournalFrontiers in Nutrition
StatePublished - Feb 16 2016

All Science Journal Classification (ASJC) codes

  • Food Science
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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