TY - GEN
T1 - Modeling the effect of temozolomide treatment on orthotopic models of glioma
AU - Vital-Lopez, Francisco G.
AU - Maranas, Costas D.
AU - Armaou, Antonios
PY - 2011/1/1
Y1 - 2011/1/1
N2 - We present a hybrid cellular-tumor level model of brain tumor progression. The model describes tumor progression as the collective outcome of individual tumor cells, the behavior of which is governed by the interplay of intracellular signaling pathways (i.e., MAPK pathway) and the spatial-temporal distribution of key biochemical cues (e.g., oxygen, growth factors). The model is deployed to simulate the effect of different schedule-dose combinations of a chemotherapeutic agent (i.e., temozolomide) on tumor growth in murine orthotopic models of glioma. Simulation results are in good quantitative agreement with experimental measurements. In addition, the model is used to predict the outcome of alternative treatment strategies. Model simulations can be helpful for designing more efficient treatment strategies.
AB - We present a hybrid cellular-tumor level model of brain tumor progression. The model describes tumor progression as the collective outcome of individual tumor cells, the behavior of which is governed by the interplay of intracellular signaling pathways (i.e., MAPK pathway) and the spatial-temporal distribution of key biochemical cues (e.g., oxygen, growth factors). The model is deployed to simulate the effect of different schedule-dose combinations of a chemotherapeutic agent (i.e., temozolomide) on tumor growth in murine orthotopic models of glioma. Simulation results are in good quantitative agreement with experimental measurements. In addition, the model is used to predict the outcome of alternative treatment strategies. Model simulations can be helpful for designing more efficient treatment strategies.
UR - http://www.scopus.com/inward/record.url?scp=80053145743&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053145743&partnerID=8YFLogxK
U2 - 10.1109/acc.2011.5990989
DO - 10.1109/acc.2011.5990989
M3 - Conference contribution
AN - SCOPUS:80053145743
SN - 9781457700804
T3 - Proceedings of the American Control Conference
SP - 2969
EP - 2974
BT - Proceedings of the 2011 American Control Conference, ACC 2011
PB - Institute of Electrical and Electronics Engineers Inc.
ER -