Modifications in surgical implantation of the Penn State Electric Total Artificial Heart

Eric M. Hoenicke; Robert G. Strange; William J. Weiss; Alan J. Snyder; Marjorie A. Rawhouser; Gerson Rosenberg; G. Allen Prophet; Walter E. Pae; Benjamin C. Sun; William S. Pierce

doi:10.1016/S0003-4975(00)02640-0

Modifications in surgical implantation of the Penn State Electric Total Artificial Heart

Eric M. Hoenicke, Robert G. Strange, William J. Weiss, Alan J. Snyder, Marjorie A. Rawhouser, Gerson Rosenberg, G. Allen Prophet, Walter E. Pae, Benjamin C. Sun, William S. Pierce

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background. Two modifications of the surgical implantation protocol for the Penn State Total Artificial Heart (ETAH) were evaluated: Phrenic nerve ischemia was prevented by minimizing dissection and traction; and hemostasis was augmented and ETAH cuff anastomoses reinforced by using fibrin glue. Methods. Thirteen Holstein calves underwent orthotopic surgical implantation of the Penn State ETAH between February 1998 and August 2000. Mean hemodynamic and laboratory chemistry variables from the first postoperative week were compared between calves receiving the original (n = 7) and modified (n = 6) protocol. Results. Calves assigned to the modified protocol displayed an improvement in the Po₂/Fio₂ ratio compared to original (419.4 ± 17.5 vs 336.3 ± 35.4, respectively; p = 0.05). All additional parameters were equivalent between groups. The percent survival of animals receiving the modified protocol at 2, 4, and 12 weeks was higher than that of animals that underwent the original protocol. Original-protocol calf deaths consisting of hemothorax (n = 3), and respiratory failure (n = 1) were prevented in the modified protocol. Conclusions. Our results suggest that manipulations in surgical protocol may promote increased survival in calves implanted with the Penn State ETAH.

Original language	English (US)
Pages (from-to)	S150-S155
Journal	Annals of Thoracic Surgery
Volume	71
Issue number	3 SUPPL.
DOIs	https://doi.org/10.1016/S0003-4975(00)02640-0
State	Published - 2001

All Science Journal Classification (ASJC) codes

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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10.1016/S0003-4975(00)02640-0

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@article{ad92bcb652ca4028b887ffc51809371f,

title = "Modifications in surgical implantation of the Penn State Electric Total Artificial Heart",

abstract = "Background. Two modifications of the surgical implantation protocol for the Penn State Total Artificial Heart (ETAH) were evaluated: Phrenic nerve ischemia was prevented by minimizing dissection and traction; and hemostasis was augmented and ETAH cuff anastomoses reinforced by using fibrin glue. Methods. Thirteen Holstein calves underwent orthotopic surgical implantation of the Penn State ETAH between February 1998 and August 2000. Mean hemodynamic and laboratory chemistry variables from the first postoperative week were compared between calves receiving the original (n = 7) and modified (n = 6) protocol. Results. Calves assigned to the modified protocol displayed an improvement in the Po2/Fio2 ratio compared to original (419.4 ± 17.5 vs 336.3 ± 35.4, respectively; p = 0.05). All additional parameters were equivalent between groups. The percent survival of animals receiving the modified protocol at 2, 4, and 12 weeks was higher than that of animals that underwent the original protocol. Original-protocol calf deaths consisting of hemothorax (n = 3), and respiratory failure (n = 1) were prevented in the modified protocol. Conclusions. Our results suggest that manipulations in surgical protocol may promote increased survival in calves implanted with the Penn State ETAH.",

author = "Hoenicke, {Eric M.} and Strange, {Robert G.} and Weiss, {William J.} and Snyder, {Alan J.} and Rawhouser, {Marjorie A.} and Gerson Rosenberg and Prophet, {G. Allen} and Pae, {Walter E.} and Sun, {Benjamin C.} and Pierce, {William S.}",

note = "Funding Information: Supported by USPHS contract 1 HV-38130 and USPHS grant 1 RO1 HL 60276-01A1.",

year = "2001",

doi = "10.1016/S0003-4975(00)02640-0",

language = "English (US)",

volume = "71",

pages = "S150--S155",

journal = "Annals of Thoracic Surgery",

issn = "0003-4975",

publisher = "Elsevier Inc.",

number = "3 SUPPL.",

}

TY - JOUR

T1 - Modifications in surgical implantation of the Penn State Electric Total Artificial Heart

AU - Hoenicke, Eric M.

AU - Strange, Robert G.

AU - Weiss, William J.

AU - Snyder, Alan J.

AU - Rawhouser, Marjorie A.

AU - Rosenberg, Gerson

AU - Prophet, G. Allen

AU - Pae, Walter E.

AU - Sun, Benjamin C.

AU - Pierce, William S.

N1 - Funding Information: Supported by USPHS contract 1 HV-38130 and USPHS grant 1 RO1 HL 60276-01A1.

PY - 2001

Y1 - 2001

N2 - Background. Two modifications of the surgical implantation protocol for the Penn State Total Artificial Heart (ETAH) were evaluated: Phrenic nerve ischemia was prevented by minimizing dissection and traction; and hemostasis was augmented and ETAH cuff anastomoses reinforced by using fibrin glue. Methods. Thirteen Holstein calves underwent orthotopic surgical implantation of the Penn State ETAH between February 1998 and August 2000. Mean hemodynamic and laboratory chemistry variables from the first postoperative week were compared between calves receiving the original (n = 7) and modified (n = 6) protocol. Results. Calves assigned to the modified protocol displayed an improvement in the Po2/Fio2 ratio compared to original (419.4 ± 17.5 vs 336.3 ± 35.4, respectively; p = 0.05). All additional parameters were equivalent between groups. The percent survival of animals receiving the modified protocol at 2, 4, and 12 weeks was higher than that of animals that underwent the original protocol. Original-protocol calf deaths consisting of hemothorax (n = 3), and respiratory failure (n = 1) were prevented in the modified protocol. Conclusions. Our results suggest that manipulations in surgical protocol may promote increased survival in calves implanted with the Penn State ETAH.

AB - Background. Two modifications of the surgical implantation protocol for the Penn State Total Artificial Heart (ETAH) were evaluated: Phrenic nerve ischemia was prevented by minimizing dissection and traction; and hemostasis was augmented and ETAH cuff anastomoses reinforced by using fibrin glue. Methods. Thirteen Holstein calves underwent orthotopic surgical implantation of the Penn State ETAH between February 1998 and August 2000. Mean hemodynamic and laboratory chemistry variables from the first postoperative week were compared between calves receiving the original (n = 7) and modified (n = 6) protocol. Results. Calves assigned to the modified protocol displayed an improvement in the Po2/Fio2 ratio compared to original (419.4 ± 17.5 vs 336.3 ± 35.4, respectively; p = 0.05). All additional parameters were equivalent between groups. The percent survival of animals receiving the modified protocol at 2, 4, and 12 weeks was higher than that of animals that underwent the original protocol. Original-protocol calf deaths consisting of hemothorax (n = 3), and respiratory failure (n = 1) were prevented in the modified protocol. Conclusions. Our results suggest that manipulations in surgical protocol may promote increased survival in calves implanted with the Penn State ETAH.

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Modifications in surgical implantation of the Penn State Electric Total Artificial Heart

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