Modulating expanded polytetrafluoroethylene vascular graft host response via citric acid-based biodegradable elastomers

Jian Yang; Delara Motlagh; Josephine B. Allen; Antonio R. Webb; Melina R. Kibbe; Oliver Aalami; Muneera Kapadia; Timothy J. Carroll; Guillermo A. Ameer

doi:10.1002/adma.200600230

Modulating expanded polytetrafluoroethylene vascular graft host response via citric acid-based biodegradable elastomers

Jian Yang, Delara Motlagh, Josephine B. Allen, Antonio R. Webb, Melina R. Kibbe, Oliver Aalami, Muneera Kapadia, Timothy J. Carroll, Guillermo A. Ameer

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86 Scopus citations

Abstract

The use of synthetic biodegradable polymers as a means to tissue-engineer a functional endothelium on expanded polytetrafluoroethylene (ePTFE) grafts was investigated. It was shown that the biodegradable elastomer poly(1,8-octanediol citrate (POC) can confer improved biocompatibility characteristics on ePTFE vascular grafts without affecting graft compliance. It was observed that synthesis of POC can be conducted under relatively low temperatures without vacuum and catalysts. It was observed that POC modification can significantly improve the hemocompatibility and acute inflammatory response of ePTFE grafts implemented in a porcine iliac artery ePTFE bypass model. It was found that the POC interface confers hydrophilicity, reduces thrombogenicity, and reduces in vivo macrophage infiltration into the ePTFE grafts.

Original language	English (US)
Pages (from-to)	1493-1498
Number of pages	6
Journal	Advanced Materials
Volume	18
Issue number	12
DOIs	https://doi.org/10.1002/adma.200600230
State	Published - Jun 19 2006

All Science Journal Classification (ASJC) codes

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.200600230

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title = "Modulating expanded polytetrafluoroethylene vascular graft host response via citric acid-based biodegradable elastomers",

abstract = "The use of synthetic biodegradable polymers as a means to tissue-engineer a functional endothelium on expanded polytetrafluoroethylene (ePTFE) grafts was investigated. It was shown that the biodegradable elastomer poly(1,8-octanediol citrate (POC) can confer improved biocompatibility characteristics on ePTFE vascular grafts without affecting graft compliance. It was observed that synthesis of POC can be conducted under relatively low temperatures without vacuum and catalysts. It was observed that POC modification can significantly improve the hemocompatibility and acute inflammatory response of ePTFE grafts implemented in a porcine iliac artery ePTFE bypass model. It was found that the POC interface confers hydrophilicity, reduces thrombogenicity, and reduces in vivo macrophage infiltration into the ePTFE grafts.",

author = "Jian Yang and Delara Motlagh and Allen, {Josephine B.} and Webb, {Antonio R.} and Kibbe, {Melina R.} and Oliver Aalami and Muneera Kapadia and Carroll, {Timothy J.} and Ameer, {Guillermo A.}",

year = "2006",

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doi = "10.1002/adma.200600230",

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T1 - Modulating expanded polytetrafluoroethylene vascular graft host response via citric acid-based biodegradable elastomers

AU - Yang, Jian

AU - Motlagh, Delara

AU - Allen, Josephine B.

AU - Webb, Antonio R.

AU - Kibbe, Melina R.

AU - Aalami, Oliver

AU - Kapadia, Muneera

AU - Carroll, Timothy J.

AU - Ameer, Guillermo A.

PY - 2006/6/19

Y1 - 2006/6/19

N2 - The use of synthetic biodegradable polymers as a means to tissue-engineer a functional endothelium on expanded polytetrafluoroethylene (ePTFE) grafts was investigated. It was shown that the biodegradable elastomer poly(1,8-octanediol citrate (POC) can confer improved biocompatibility characteristics on ePTFE vascular grafts without affecting graft compliance. It was observed that synthesis of POC can be conducted under relatively low temperatures without vacuum and catalysts. It was observed that POC modification can significantly improve the hemocompatibility and acute inflammatory response of ePTFE grafts implemented in a porcine iliac artery ePTFE bypass model. It was found that the POC interface confers hydrophilicity, reduces thrombogenicity, and reduces in vivo macrophage infiltration into the ePTFE grafts.

AB - The use of synthetic biodegradable polymers as a means to tissue-engineer a functional endothelium on expanded polytetrafluoroethylene (ePTFE) grafts was investigated. It was shown that the biodegradable elastomer poly(1,8-octanediol citrate (POC) can confer improved biocompatibility characteristics on ePTFE vascular grafts without affecting graft compliance. It was observed that synthesis of POC can be conducted under relatively low temperatures without vacuum and catalysts. It was observed that POC modification can significantly improve the hemocompatibility and acute inflammatory response of ePTFE grafts implemented in a porcine iliac artery ePTFE bypass model. It was found that the POC interface confers hydrophilicity, reduces thrombogenicity, and reduces in vivo macrophage infiltration into the ePTFE grafts.

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DO - 10.1002/adma.200600230

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JO - Advanced Materials

JF - Advanced Materials

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Modulating expanded polytetrafluoroethylene vascular graft host response via citric acid-based biodegradable elastomers

Abstract

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