TY - JOUR
T1 - Modulation of autoimmune diseases by iPS cells
AU - Lei, Fengyang
AU - Haque, Rizwanul
AU - Xiong, Xiaofang
AU - Song, Jianxun
N1 - Publisher Copyright:
© Springer Science+Business Media New York 2014.
PY - 2014
Y1 - 2014
N2 - Autoimmune disease is typically caused by the activated self-reacted immune cells. The mainstream treatment to autoimmune disorders is composed of different mechanisms of immunosuppression. In recent years, a new subtype of T cells called regulatory T (Treg) cells have been identifi ed to maintain the immune homeostasis in terms of suppressing the activated immune components. According to this discovery, it is suggested that treating autoimmune patients by supplementing Treg cells would be a good choice. However, due to their natural scarcity, it is diffi cult to isolate a desired number of Treg for this therapeutical approach. Here, we report that by using stem cells, especially the induced pluripotent stem (iPS) cells, we are able to generate a signifi cant amount of Treg cells for the autoimmune prevention and treatment.
AB - Autoimmune disease is typically caused by the activated self-reacted immune cells. The mainstream treatment to autoimmune disorders is composed of different mechanisms of immunosuppression. In recent years, a new subtype of T cells called regulatory T (Treg) cells have been identifi ed to maintain the immune homeostasis in terms of suppressing the activated immune components. According to this discovery, it is suggested that treating autoimmune patients by supplementing Treg cells would be a good choice. However, due to their natural scarcity, it is diffi cult to isolate a desired number of Treg for this therapeutical approach. Here, we report that by using stem cells, especially the induced pluripotent stem (iPS) cells, we are able to generate a signifi cant amount of Treg cells for the autoimmune prevention and treatment.
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U2 - 10.1007/978-1-4939-1453-1_30
DO - 10.1007/978-1-4939-1453-1_30
M3 - Article
C2 - 25173398
AN - SCOPUS:84929512641
SN - 1064-3745
VL - 1213
SP - 365
EP - 377
JO - Methods in Molecular Biology
JF - Methods in Molecular Biology
ER -